Gastroprotective effects of extract of Jasminum grandiflorum L. flower in HCl/EtOH-induced gastric mucosal ulceration mice - 13/11/21

Doi : 10.1016/j.biopha.2021.112268

Yizi Zhang ^a,^{^{1
These authors contributed equally to this work.}}, Lingli Sun ^b,^{^{1
These authors contributed equally to this work.}}, Xingfei Lai ^b, Xingjia Peng ^a, Shuai Wen ^b, Zhenbiao Zhang ^b, Yinzheng Xie ^a, Qiuhua Li ^b, Ruohong Chen ^b, Xi Zheng ^a, Kun Zhang ^a, Shili Sun ^b,^⁎ , Dongli Li ^a,^c,^⁎
^a School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China
^b Tea Research Institute, Guangdong Academy of Agricultural Sciences / Guangdong Key Laboratory of Tea Resources Innovation & Utilization, Guangzhou 510640, China
^c International Healthcare Innovation Institute (Jiangmen), Jiangmen 529040, China

^⁎Corresponding author.^⁎⁎Corresponding author at: School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China.School of Biotechnology and Health Sciences, Wuyi UniversityJiangmen529020China

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Abstract

Jasminum grandiflorum L. is a medicinal plant used to treat hepatitis and gastritis, but the mechanisms underlying its protective effects against gastrointestinal mucosal damage remain to be elucidated. In this study, we analyzed the effects of four different extracts and two compounds from the flower of J. grandiflorum in a mouse model of HCl/EtOH-induced gastric ulcer. The flower extracts alleviated gastric mucosal ulceration by increasing PGE2 production and the activity of antioxidant enzymes, along with the suppression of reactive oxygen species (ROS) generation, lipid peroxidation, apoptosis-related proteins, pro-inflammatory cytokines and nitric oxide (NO) production.

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Highlights

•	PET extract of J. grandiflorum flowers and compound HT exert gastroprotective effects.
•	PET alleviates gastric mucosal ulcer in mice by regulating the NF-κB pathway.
•	HT alleviates gastric mucosal injury in mice mainly by reducing oxidative stress.
•	PET has a potent anti-inflammatory effect in LPS-stimulated RAW264.7 macrophages.

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Keywords : Inflammation, Oxidative stress, Gastrointestinal mucosal damage, Apoptosis

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Gastroprotective effects of extract of Jasminum grandiflorum L. flower in HCl/EtOH-induced gastric mucosal ulceration mice - 13/11/21

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