Altered serum soluble furin and prorenin receptor levels in pregnancies with pre-eclampsia and fetal growth restriction - 19/11/21
, Asuka Kato a, Hikari Yoshizawa a, b, Jun Miyazaki a, b, Yoshiteru Noda a, b, Yoshiko Sakabe a, b, Takao Sekiya a, Takuma Fujii a, Hiroki Kurahashi bBienvenue sur EM-consulte, la référence des professionnels de santé.
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Abstract |
Objective |
The proprotein convertase furin is known to be involved in the processing of pro-B-type natriuretic peptide (proBNP) and prorenin receptor (PRR), suggesting that it has a potential function in blood pressure regulation. We investigated the role of furin in the etiology of pre-eclampsia and its related disorder, unexplained fetal growth restriction (FGR) without hypertension.
Methods |
We evaluated serum and placental furin levels in pre-eclampsia, FGR and uncomplicated pregnancy. Additionally, we investigated the correlation between the serum furin levels and products of furin enzymatic activity or clinical parameters.
Results |
We demonstrated that the maternal circulation in cases of pre-eclampsia and FGR had lower levels of soluble furin than uncomplicated pregnancies. Both NT-proBNP and soluble PRR were elevated in pre-eclampsia, whereas only soluble PRR was at higher levels in unexplained FGR. Linear regression analysis revealed a negative correlation between the serum furin level and that of NT-proBNP or soluble PRR. While we observed that the serum furin or soluble PRR level correlated with blood pressure, a stronger correlation was observed with birth and placental weights. Further to this, the FURIN mRNA levels were significantly reduced in placental pre-eclamptic placentas as well as in FGR cases.
Conclusion |
These data suggest the possibility that reduced levels of furin may be the result of a negative feedback from the activation of the renin-angiotensin pathway that leads to feto-placental dysfunction with or without maternal hypertension. This may represent an etiologic pathway of pre-eclampsia and unexplained FGR.
Le texte complet de cet article est disponible en PDF.Keywords : Furin, Pre-eclampsia, Fetal growth restriction, Prorenin receptor, NT-proBNP
Plan
Vol 50 - N° 10
Article 102198- décembre 2021 Retour au numéro
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