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Frequency and status of depression and anxiety in mothers of children with inborn errors of metabolism with restricted diet, with and without risk of metabolic crises - 25/11/21

Doi : 10.1016/j.arcped.2021.09.008 
Pelin Teke Kisa a, b, Ozlem Unal Uzun c, Mehmet Gunduz d, Fatma Selda Bulbul e, Engin Kose f, Nur Arslan a, g,
a Dokuz Eylul University Faculty of Medicine, Department of Pediatric Metabolism and Nutrition, Izmir, Turkey 
b University of Health Sciences, Dr. Behçet Uz Children's Research and Training Hospital, Department of Pediatric Metabolism and Nutrition, Izmir, Turkey 
c Kocaeli University Faculty of Medicine, Department of Pediatric Metabolism and Nutrition, Kocaeli, Turkey 
d Ministry of Health Ankara City Hospital, Department of Pediatric Metabolism and Nutrition, Ankara, Turkey 
e Kirikkale University Faculty of Medicine, Department of Pediatric Metabolism and Nutrition, Kirikkale, Turkey 
f Ankara University Faculty of Medicine, Department of Pediatric Metabolism and Nutrition, Ankara, Turkey 
g Izmir Biomedicine and Genome Center, Izmir, Turkey 

Corresponding author at: Dokuz Eylul University Faculty of Medicine, Department of Child Health and Diseases, Division of Pediatric Metabolism and Nutrition, Izmir, Izmir, Biomedicine and Genome Center (İBG-izmir), 35340 Balcova Izmir, Turkey.Dokuz Eylul University Faculty of Medicine, Department of Child Health and Diseases, Division of Pediatric Metabolism and Nutrition, Izmir, Izmir, Biomedicine and Genome Center (İBG-izmir)BalcovaIzmir35340Turkey

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Abstract

Objectives

This study aimed to investigate the frequency and status of depression and anxiety among mothers of children with inborn errors of metabolism (IEM) who were on a restricted diet and previously experienced metabolic crises.

Methods

This cross-sectional multicenter descriptive study included 93 children with IEM who were on restricted diet. The patients were divided into two groups: those who had experienced metabolic crises (n=44, urea cycle defect, organic acidemia, maple syrup urine disease, hereditary fructose intolerance) and those who had not experienced previous metabolic crises (n=49; phenylketonuria, galactosemia, and non-ketotic hyperglycinemia). The control group comprised 37 healthy children. The mothers of the patients and control participants answered a questionnaire about their and their children's demographic and clinical characteristics and completed the Beck Depression Inventory (BDI) and the State-Trait Anxiety Inventory (STAI-S and STAI-T).

Results

The maternal BDI, STAI-S, and STAI-T scores were 6.3±5.2, 36.1±11.2, and 39.9±8.8, respectively, in the control group. The maternal BDI, STAI-S, and STAI-T scores of the children who had experienced (19.2±9.7; 44.0±12.4; 47.9±10.6) and those who had not experienced (13.9±9.1; 40.7 ±8.6; 45.3±8.3) a crisis were significantly higher than for the controls. The BDI score was significantly higher for the mothers of children who had experienced a crisis (p=0.011), whereas no significant difference was determined between the two patient groups regarding STAI-S and STAI-T scores. The mothers of four children who had experienced metabolic crises were on antidepressant therapy.

Conclusion

Although their children were on a similar restricted diet, the mothers of children who previously experienced or who had the risk of experiencing metabolic crises had higher depression scores as compared with the mothers of children who did not experience a previous crisis. Early supportive therapy may be required for the families of these patients to lower the burden of stress.

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Keywords : Metabolic crises, Inborn errors of metabolism, Anxiety, Depression, Mother


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Vol 28 - N° 8

P. 702-706 - novembre 2021 Retour au numéro
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