Impact of disease-modifying treatments on humoral response after COVID-19 vaccination: A mirror of the response after SARS-CoV-2 infection - 02/12/21
, L. Kremer a, b, M. Fleury a, L. Lanotte a, b, N. Collongues a, b, J. de Seze a, b
Bienvenue sur EM-consulte, la référence des professionnels de santé.
Article gratuit.
Connectez-vous pour en bénéficier!
Abstract |
Objective |
To analyze the humoral response after COVID-19 vaccination in patients with multiple sclerosis (MS) according to disease-modifying treatments (DMTs) and in comparison with the humoral response after SARS-CoV-2 infection.
Methods |
We included 28 MS patients with serological results after COVID-19 vaccination (Pfizer-BioNTech or Moderna ARNm) and 61 MS patients with serological results after COVID-19 (COVID-19 group) among patients followed up at the MS Center of Strasbourg, France, between January and April 2021. The primary endpoint was the IgG index according to DMTs (anti-CD20 mAb, sphingosine 1-phosphate receptor [S1PR] modulator and other treatments) and COVID-19 vaccine or COVID-19 groups.
Results |
In the vaccinated MS patients, the median IgG index was lower in patients treated with anti-CD20 mAb and in patients treated with S1PR modulator compared to patients receiving other or no DMTs (4.80 [1.58–28.6], 16.5 [16.3–48.5], 1116 [434–1747] and 1272 [658–1886], respectively, P<0.001). Similar results were found for MS patients after COVID-19.
Conclusions |
Patients with MS and treated with S1PR modulators or anti-CD20 mAb had a reduced humoral response after COVID-19 vaccine.
Le texte complet de cet article est disponible en PDF.Keywords : Multiple sclerosis, COVID-19, Vaccine, Humoral response, Antibody
Plan
Vol 177 - N° 10
P. 1237-1240 - décembre 2021 Retour au numéro
Article précédent
- Psycho-sensory modalities of visual hallucinations and illusions in Parkinson's disease
- A. Marques, S. Beze, C. Lambert, L. Bonamy, I. de Chazeron, I. Rieu, F. Chiambaretta, F. Durif
- Clinical failure of natalizumab in multiple sclerosis: Specific causes and strategy
- D. Guery, R. Marignier, F. Durand-Dubief, C. Lavie, J. Pique, O. Guerrier, S. Vukusic
Bienvenue sur EM-consulte, la référence des professionnels de santé.