Metastasis to the oral and maxillofacial region. A systematic review. - 24/12/21

Doi : 10.1016/j.jormas.2021.12.009

Alberto Jose Peraza Labrador ^a,^⁎ , Nestor Ricardo Gonzalez Marin ^b, Luciano Hermios Matos Valdez ^c, Katman Bear Toledo Sanchez ^d, Wil Zabarburu ^e, Karem Annelise Rodriguez Ibazetta ^f, Alejandra Elvia Ruiz Garcia ^g, Dayana Mamani Cabezas ^h, Leonardo Romero ⁱ, Aldo Manzur Conte ^j, John M Wright ^k
^a Oral surgeon and oral pathologist director centro de odontologia integral acarigua, Mailing address: av 5 de diciembre cc metropolitan local 6, Venezuela
^b Professor of Department of Otolaryngologist Military Hospital Bogota, Colombia
^c Oral Patohology director. Diagnocentrobucal, Mailing address: Las Golondrinas Mz. B lote 9, Los Olivos, Lima, Peru
^d Resident oral pathology program cayetano Heredia peru. Oral and maxilofacial pathology and medicine clinics, Mailing address: Av. El Olivar, 3879 San Martin de Porres, Lima, Peru
^e Director of Dental healthcare clinic, Av principal Lote 7. Micaela Bastidas 2, Lima, Peru
^f Associated of Oral and maxilofacial pathology and medicine clinics department. Mailing address: Av. Pablo Carriquiry 705, San Isidro, Lima, Peru
^g Director Oral and maxilofacial pathology and medicine clinics. Mailing address: Cooperativa Santa Polonia Mz. N lote 15, San Martin de Porres, Lima, Peru
^h Director associated. Oral and maxilofacial pathology and medicine clinics. Mailing address: Av. Petrolera km 4 Zona Sud OTB Villa San Miguel, Cochabamba, Bolivia
ⁱ Dircetor of the Oral prostodontic department. Romedent dental clinic, Bogotá, Colombia
^j Director of endodontic department. Savanna Dental Group, 1135 Adelaide St. North suite 303, London, Ontario N5Y 5K7, Canada
^k Department of Diagnostic Sciences, Texas A&M University College of Dentistry, 3302 Gaston Ave, Dallas, TX 75246, United States

^⁎Corresponding author at: Oral surgeon and oral pathologist director centro de odontologia integral acarigua, Mailing address: av 5 de diciembre cc metropolitan local 6. Venezuela.Oral surgeon and oral pathologist director centro de odontologia integral acariguaMailing address: av 5 de diciembre cc metropolitan local 6Venezuela

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Abstract

Objective

Metastasis to oral and maxillofacial region (MOMFR) is an unusual finding; representing between 1 and 1.5% of all malignancies in the maxillofacial region. A systematic review is presented to determine trends in presentation, diagnostic features, and patient outcome.

Methods

Searches of databases were carried out for papers reporting MOMFR. The variables were demographics, patient symptoms, tumor location, tumor size, histopathology, origin of the tumor, immunohistochemical studies, follow-up and survival.

Results

696 cases were identified; 391 males, and 305 females. The most common race was white. The most common primary tumor for females was from breast 31.1% (n = 95), for males from lung 20.5% (n = 143). The most common location was the mandible 44.9% (n = 313), followed by gingival soft tissue 16.8% (n = 117). A frequent clinical symptom was pain with 17.5% (n = 122). The most common clinical presentation was a mass or tumor 37.4% (n = 260). The mean age was 58.8 years. The average time before diagnosis was 10.3 months, the mean follow-up after diagnosis was 13.1 months, and the average survival was 9.8 months.

Conclusion

MOMFR shows a strong predilection for the posterior mandible, with a mass or tumor being the most common clinical presentation. They are frequently painful, and demonstrate a poor prognosis.

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Keywords : Neoplasm metastasis, Gingival neoplasms, Jaw neoplasms, Mouth diseases, Mouth neoplasms, Immunohistochemistry