Percutaneous screw fixation of pelvic bone metastases using cone-beam computed tomography navigation - 13/01/22

Doi : 10.1016/j.diii.2022.01.002

Francois H. Cornelis ^a,^b,^⁎ , Leo Razakamanantsoa ^a, Mohamed Ben Ammar ^a, Milan Najdawi ^a, Sanaa El-Mouhadi ^c, Francois Gardavaud ^a, Matthias Barral ^a
^a Department of Interventional Radiology and Oncology, Sorbonne Université, Tenon Hospital, AP-HP, 75020 Paris, France
^b Memorial Sloan Kettering Cancer Center, Interventional Radiology, 10065 New York, NY, USA
^c Department of Radiology, Saint Antoine Hospital, AP-HP, 75012 Paris, France

^⁎Corresponding author.

Sous presse. Épreuves corrigées par l'auteur. Disponible en ligne depuis le Thursday 13 January 2022
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Highlights

•	Percutaneous screw fixation of pelvic bone metastases performed using cone beam CT navigation is feasible and safe.
•	The use of CBCT navigation and manual drawing of the entry point directly on patient skin is effective to overcome possible limitations due to steep angulations.
•	Procedure duration is not significantly longer in patients with mixed or blastic pelvic bone metastases compared to those with lytic metastases.
•	No significant correlation is observed between procedure duration and number of screws inserted and need for manual drawing of the entry point.

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Abstract

Purpose

The purpose of this study was to evaluate the efficacy of cone-beam computed tomography (CBCT) navigation to achieve percutaneous screw fixation (PSF) of pelvic bone metastases (PBM).

Materials and methods

Thirty-five consecutive patients (12 men and 23 women; mean age, 62 ± 11.3 [SD]; range: 39–89 years) treated between 2019 and 2021 were retrospectively included. CBCT navigation software was systematically used. Manual drawing of the entry point (MDEP) was performed when CBCT automatic positioning failed. Influence of metastasis pattern, ablation, body mass index, number of screws, and MDEP on procedure duration (PD) and total Air Kerma (AK) was evaluated. Local pain was assessed before, one and six months after treatment. Variables were compared using Pearson correlation, Student t and Wilcoxon tests.

Results

Seventy-five screws were inserted successfully (mean: 2.1 ± 1.1 [SD]; range: 1–5 per patient). CBCT automatic positioning was obtained for 41 screws (55%, 41/75), whereas 34 (45%, 34/75) required MDEP. Mean procedure duration, fluoroscopy time, kerma air product and AK were 73.3 ± 44.8 (SD) min (range: 19–233 min), 13.1 ± 9.5 (SD) min (range: 1.4–38.6 min), 73.8 ± 66.3 (SD) Gy.cm² (range: 11.6–303.7 Gy.cm²) and 301.7 ± 242.1 (SD) mGy (range: 49.4–1111.5 mGy), respectively. Procedure duration was not significantly longer in patients with mixed or blastic PBM compared to those with lytic PBM or when performing ablation, and no significant correlations were observed with the number of screws inserted (P = 0.19), MDEP (P = 0.37) and BMI (P = 0.44). No adverse events were reported during the follow-up (median: 6 months; IQR: 6–6.5 months). Thirteen patients died during the follow-up related to cancer progression. Local pain decreased from 35 ± 32 (SD) mm (range: 0–10 mm) to 11 ± 20 (SD) mm (range: 0–80 mm) at one month (P = 0.001); and to 22 ± 23 (SD) mm (range: 0–60 mm) at six months (P = 0.001).