A meta-analysis on the presentation of Unicystic Ameloblastoma in the jaws and the consequences for their treatment - 15/01/22

Doi : 10.1016/j.jormas.2022.01.004

Yuri Slusarenko da Silva ^a, Karpal Singh Sohal ^b, Paul J.W. Stoelinga ^c, Ricardo Grillo ^d,^⁎
^a School of Dentistry – UniFG University Center (Faculty of Guanambi), Bahia, Brazil
^b Department of Oral and Maxillofacial Surgery, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania
^c Department of Oral and Maxillofacial Surgery, Radboud University, Nijmegen, the Netherlands
^d Department of Oral & Maxillofacial Surgery, Faculdade São Leopoldo Mandic, School of Dentistry, Rua Dr. José Rocha Junqueira 13 Ponte Preta – Campinas, São Paulo 13045-755, Brazil

^⁎Corresponding author.

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Abstract

Introduction

This meta-analysis provides reliable data on the prevalence of unicystic ameloblastomas (UA's) among solid/multicystic ameloblastomas (SMA's), as well the ratio of their presence in the maxilla and mandible and in the tooth-bearing area versus the posterior regions of the mandible, including the third molar region and ascending ramus.

Material and methods

A systematic review and meta-analysis was performed according to PRISMA guideline using the strategy ((unicystic ameloblastoma) OR (((ameloblastoma) OR (solid ameloblastoma)) OR (multicystic ameloblastoma))) NOT ((((systematic review) OR (literature review)) OR (case report)) OR (Immunohistochemical)).

Discussion

The study included 3856 SMA's and 1537 UA's, which amounted to 28.5% UA's. Of the 380 cases of UA from twelve articles that mentioned the involved jaws, 355 were in the mandible and 25 in the maxilla. The preponderance for the mandible is much higher than reports from previous studies of smaller series. Only five articles mentioned the location within the mandible. The vast majority was in the posterior area.

Conclusion

The consequences for treatment were discussed, with an emphasis on the approach to unicystic lesions in the posterior part of the mandible for which a protocol is suggested.

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Keywords : Ameloblastoma, Meta-analysis, Odontogenic tumors, Unicystic ameloblastoma