FGF19 protects against obesity-induced bone loss by promoting osteogenic differentiation - 16/01/22
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Abstract |
Human fibroblast growth factor 19 (FGF19) has become a potential therapeutic target for metabolic-related diseases. However, the effects of FGF19 on obesity-induced bone loss have not been completely elucidated. The aim of this study was to investigate the protective effects of FGF19 in high-fat diet (HFD)-fed obese mice and palmitic acid (PA)-treated osteoblasts and to further explore its underlying mechanisms. In vivo, we found that FGF19 alleviated the decreased bone mineral density (BMD) induced by HFD. Micro-CT analysis of femur samples and histological analysis indicated that FGF19 alleviated HFD-induced loss of bone trabeculae and damage to the bone trabecular structure. In vitro, the results suggested that FGF19 ameliorated the PA-induced decline in osteoblast proliferation, increased cell death and impaired cell morphology. Additionally, FGF19 protected against the decline in activation of alkaline phosphatase (ALP) and protein expression of Collagen-1, Runx-2, and osteopontin (OPN) induced by PA. Furthermore, FGF19 might enhance osteogenic differentiation via the Wnt/β-catenin pathway and inhibit osteoclastogenesis by regulating the osteoprotegerin (OPG)/receptor activator of NF-κB ligand (RANKL) axis, thus attenuating the negative effect of PA in osteoblasts. In conclusion, our results suggested that FGF19 might promote osteogenic differentiation partially through activation of the Wnt/β-catenin pathway and alleviate obesity-induced bone loss.
Le texte complet de cet article est disponible en PDF.Highlights |
• | FGF19 ameliorates bone loss in young and aged obese mice. |
• | FGF19 alleviates the inhibitory effect of PA on osteogenic differentiation. |
• | FGF19 promotes osteogenic differentiation by regulating the Wnt/β-catenin pathway. |
• | FGF19 is a potential therapeutic target for bone-related diseases. |
Keywords : FGF19, Obesity, High-fat diet, Osteoblast, Bone loss
Plan
Vol 146
Article 112524- février 2022 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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