Traditional Chinese medicine for precancerous lesions of gastric cancer: A review - 16/01/22
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Abstract |
Gastric cancer (GC) is the fifth most common type of cancer and the third leading cause of death due to cancer worldwide. The gastric mucosa often undergoes many years of precancerous lesions of gastric cancer (PLGC) stages before progressing to gastric malignancy. Unfortunately, there are no effective Western drugs for patients with PLGC. In recent years, traditional Chinese medicine (TCM) has been proven effective in treating PLGC. Classical TCM formulas and chemical components isolated from some Chinese herbal medicines have been administered to treat PLGC, and the main advantage is their comprehensive intervention with multiple approaches and multiple targets. In this review, we focus on recent studies using TCM treatment for PLGC, including clinical observations and experimental research, with a focus on targets and mechanisms of drugs. This review provides some ideas and a theoretical basis for applying TCM to treat PLGC and prevent GC.
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Highlights |
• | This review summarized the mainly classification of syndrome differentiation of PLGC. |
• | This review summarized the therapy of Chinese medicine formulas or components on PLGC. |
• | This review listed the pharmacological mechanisms of the TCM for PLGC. |
Abbreviations : GC, PLGC, TCM, CAG, IM, GIN, H. pylori:, BXD, WFC, QLSP, WPL, WPX, HZJD, DOP, EGCG, ASIV, NGR1, Rg3, BBR, ZJP, TNF-α, NF-κB, COX-2, VEGF, MVD, MMP-2, PGE2, TFF, HSP70, EGF, PG, HSP, HIF-1, EMT
Keywords : Precancerous lesions of gastric cancer, Traditional Chinese medicine, Pattern differentiation, Formulas, Pharmacological mechanism
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Vol 146
Article 112542- février 2022 Retour au numéro
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