Multi-activity tetracoordinated pallado-oxadiazole thiones as anti-inflammatory, anti-Alzheimer, and anti-microbial agents: Structure, stability and bioactivity comparison with pallado-hydrazides - 16/01/22
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Abstract |
Herein, we report a comparative study based on structure, thermal and solution stability, and biopotency against lipoxygenase (LOX), butyrylcholinesterase (BChE) and microbes for Pd(II) compounds of N,O,S bearing 5-(C5H4XR)-1,3,4-oxadiazole-2-thiones (L′) of type [PdL′Cl2] (P′n) and N,O bearing respective hydrazides (L) of type trans-[PdL2Cl2] (Pn) {X = C, R = 4-I, 2-Br, 4-NO2, 3-NO2, 2-Cl, 3-Cl (n = 1–6, serially); X = N (n = 7)}. Spectral techniques (IR, EI-MS, NMR) and physicochemical evaluations successfully characterized the new compounds. The L′ behaved as bidentate S-N donors bonded through exocyclic sulfur and N-3′ nitrogen, while L acted as amino N donors. UV–vis (solution speciation) and thermal degradation profiles consistently confirmed the greater stability for P′n than Pn compounds. These compounds manifested varying degree in vitro potential to inhibit LOX, BChE and several bacteria and fungi, affected mainly by Pd(II) presence, M-L binding mode, nature and position of R, or halo groups electronegativity. Molecular docking with human 5-LOX and BChE further validated the respective experimental inhibition findings and explored several putative mechanistic interactions (H-bonding, π-stacking, π-alkyl, π-S, etc.) at the enzyme active sites. Pn generally offered superior antimicrobial and anti-LOX (anti-inflammatory) potential than respective P′n compounds, with P3/P′5, P(2,3,7)/P′3, and P6 being comparable, better and equivalent to ampicillin, nystatin and baicalein, the reference antibacterial, antifungal and anti-LOX drugs, respectively. Contrarily, the anti-BChE activity of P′n was found better than Pn compounds, showing P′2/P1 as the most promising anti-Alzheimer drug candidates. This study bares important structural and mechanistic aspects in optimizing antimicrobial, anti-inflammatory and anti-Alzheimer activities, highlighting some potential future pallado-drug candidates.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Six Pd(II) compounds of 5-(R′)-1,3,4-oxadiazole-2-thiones were synthesized, characterized, and evaluated for solution, thermal and biological behaviors, and compared with respective Pd(II)-hydrazides. Both compound types show promising in vitro antimicrobial, anti-inflammatory and anti-Alzheimer activities with interesting structure-activity relationships, validated in-silico.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Synthesis & characterization of new pallado-5-(R′)-1,3,4-oxadiazole-2-thiones, Pd-odt. |
• | Solution, thermal & biological behaviors of Pd-odt versus Pd-hydrazides (Pd-hz). |
• | Biological and coordinating chelate properties of Pd-odt (N,O,S) versus Pd-hz (N,O). |
• | Multi-biopotency against bacteria, fungi, inflammation & Alzheimer with interesting SAR. |
• | In vitro & in silico studies of lipoxygenase and butyrylcholinesterase inhibition. |
Keywords : Palladium complex, 2-Meracapto-5-(aryl)-1,3,4-oxadiazole, Acid hydrazide, Spectroscopy, S-N chelate, In silico study
Plan
Vol 146
Article 112561- février 2022 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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