Curcumin combined with photodynamic therapy, promising therapies for the treatment of cancer - 16/01/22
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Abstract |
Curcumin, a phytochemical derived from the rhizome of turmeric (Curcuma longa L.), has a broad group of substances with antibacterial, anti-inflammatory, anti-oxidant, anticancer activities. The anticancer activity of curcumin and its derivatives are mainly related to its regulation of signal transduction pathways. However, due to the low oral availability of curcumin, fast metabolism and other pharmacokinetic properties limit the application of curcumin in the treatment of cancer. Evidence suggests that curcumin combined with photodynamic therapy can overcome the limitation of curcumin's low bioavailability by acting on apoptosis pathways, such as B-cell lymphoma 2 (Bcl-2) and caspase family, and affecting cell cycle. This paper reviews the structure and pharmacokinetics of curcumin, focusing on the anticancer activity of curcumin combined with photodynamic therapy and the effects on cancer-related signal pathways.
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Highlights |
• | Photodynamic therapy can greatly enhance curcumin’s anticancer activity. |
• | Curcumin combined with photodynamic therapy have been confirmed in many different types of cancer cells in vitro and animal models. |
• | This review focuses on the anticancer activity and the mechanism of curcumin combined with photodynamic therapy. |
Abbreviations : Bcl-2, PDT, THC, HHC, UGT, WHO, UVA, VIS, NF-κB, ROS, Bax, AuNPs, Cur-LDH, Apaf-1, PARP, JUN
Keywords : Curcumin, Photodynamic therapy, Anticancer, Apoptosis, Mitochondria, Cell cycle
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Vol 146
Article 112567- février 2022 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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