The role of ubiquitin-specific peptidases in glioma progression - 16/01/22
, Xinjun Wang a, c, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
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| pages | 11 |
| Iconographies | 5 |
| Vidéos | 0 |
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Abstract |
The balance between ubiquitination and deubiquitination is crucial for protein stability, function and location under physiological conditions. Dysregulation of E1/E2/E3 ligases or deubiquitinases (DUBs) results in malfunction of the ubiquitin system and is involved in many diseases. Increasing reports have indicated that ubiquitin-specific peptidases (USPs) play a part in the progression of many kinds of cancers and could be good targets for anticancer treatment. Glioma is the most common malignant tumor in the central nervous system. Clinical treatment for high-grade glioma is unsatisfactory thus far. Multiple USPs are dysregulated in glioma and have the potential to be therapeutic targets. In this review, we collected studies on the roles of USPs in glioma progression and summarized the mechanisms of USPs in glioma tumorigenesis, malignancy and chemoradiotherapy resistance.
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Highlights |
• | Aberrant USPs expression existed in glioma and correlated with survival of patients. |
• | TGF-β, β-catenin, PDGF and Hh signals involved in gliomagenesis regulated by USPs. |
• | USPs increased glioma malignancy by regulating migration, invasion and stemness. |
• | USPs regulated glioma resistance by apoptosis, DNA repair and autophagy pathways. |
• | USPs might be potential therapeutic targets for glioma. |
Keywords : Deubiquitinases, Ubiquitin-specific peptidases, Glioma
Plan
Vol 146
Article 112585- février 2022 Retour au numéro
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