Polyphenols inhibiting MAPK signalling pathway mediated oxidative stress and inflammation in depression - 16/01/22
, Tarapati Rana a, b, Ghallab H. Alotaibi c, Md. Shamsuzzaman c, Maaz Naqvi d, Aayush Sehgal a, Sukhbir Singh a, Neelam Sharma a, Yosif Almoshari e, Ahmed A.H. Abdellatif f, g, Muhammad Shahid Iqbal h, Saurabh Bhatia i, j, Ahmed Al-Harrasi i, Simona Bungau k, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Abstract |
Depression is one of the most debilitating psychiatric disorders affecting people of all ages worldwide. Despite significant heterogeneity between studies, increased inflammation and oxidative stress have been found in depression. Oxidative stress and inflammation are involved in the pathogenesis of depression. In the current review, we discussed the markers of oxidative stress and inflammation in depressive disorder and the association between these markers and the antidepressant treatment. The role of natural polyphenols in regulating various cell signaling pathways related to oxidative stress and inflammation has also been reviewed. The inhibitory effect of polyphenols on several cell signaling pathways reveals the vital role of polyphenols in the prevention and treatment of depressive disorder. Understanding the mechanism of polyphenols implicated in the regulation of cell signaling pathways is essential for the identification of lead compounds and the development of novel effective compounds for the prevention and treatment of depressive disorder.
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Highlights |
• | Oxidative stress and inflammation are involved in the pathogenesis of depression. |
• | Reactive oxygen species activate various cell signaling pathways. |
• | Polyphenols inhibit the activation of oxidative stress-induced signaling pathways. |
• | Polyphenols suppress oxidative stress and inflammation in depressive disorder. |
• | Polyphenols exhibit antioxidative and anti-inflammatory effects. |
Keywords : Oxidative stress, Depression, Antidepressants, Inflammation, Psychiatric disorders
Plan
Vol 146
Article 112545- février 2022 Retour au numéro
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