Are plasma proteins a valid alternative for assessing nephrotic syndrome in children from low-income countries? - 08/05/22
ABSTRACT |
Background |
A diagnosis of nephrotic syndrome (NS) in children with edema relies on urinary albumin excretion and usually plasma protein (Pprot) and albumin (Palb) concentrations.
Methods |
In order to fit laboratory tests to optimal healthcare in low-resource countries, we established correlations between Pprot and Palb in children with NS (217 measurements in 60 patients) and in children with exudative enteropathy and chronic hepatopathy/liver insufficiency (186 measurements in 21 patients); all patients had repeated measurements at various stages of their disease.
Results |
There was a good correlation between Pprot and Palb in children with idiopathic NS and genetic NS (ICC=0.8, p < 0.0001, 95% CI: 0.8–0.9 and ICC=0.8, p < 0.0001, 95% CI: 0.7–0.8, respectively), whereas the correlation was average (exudative enteropathy) or absent (chronic hepatopathy) in those without renal protein loss.
Conclusion |
Since Palb measurement is around two times more expensive than Pprot measurement, these results suggest giving priority to total Pprot measurement in the diagnosis and follow-up of children with the NS, mainly in low-resource countries.
Le texte complet de cet article est disponible en PDF.Keywords : Plasma albumin, Plasma protein, Nephrotic syndrome, Exudative enteropathy, Chronic hepatopathy
Plan
Vol 29 - N° 4
P. 263-266 - mai 2022 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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