Update of the current role of ultrasound in asymptomatic hyperuricemia. A systematic literature review - 08/05/22

Doi : 10.1016/j.jbspin.2021.105335

Marwin Gutierrez ^a,^b, Hugo Sandoval ^c, Chiara Bertolazzi ^a, Carina Soto-Fajardo ^a, Rene Martin Tellez-Gastelum ^d, Anthony M. Reginato ^e,^f, Denise Clavijo-Cornejo ^a,^⁎
^a Division of Musculoskeletal and Rheumatic Diseases, Instituto Nacional de Rehabilitacion, Mexico City, Mexico
^b Center of Excellence in Rheumatology, Mexico City, Mexico
^c Sociomedical Research Unit, Instituto Nacional de Rehabilitacion, Mexico City, Mexico
^d Electron Microscopy Laboratory, Instituto Nacional de Rehabilitacion, Mexico City, Mexico
^e Division of Rheumatology, Department of Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island
^f Department of Dermatology, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island

^⁎Corresponding author at: Division of Musculoskeletal and Rheumatic Diseases, Instituto Nacional de Rehabilitación, Luis Guillermo Ibarra Ibarra, Calzada México–Xochimilco 289. CP.14389, Mexico city, Mexico.Division of Musculoskeletal and Rheumatic Diseases, Instituto Nacional de Rehabilitación, Luis Guillermo Ibarra Ibarra, Calzada México–Xochimilco 289. CP.14389Mexico cityMexico

Highlights

•	US is able to detect MSU-crystal deposits in asymptomatic hyperuricemia individuals in pre-gout state.
•	In asymptomatic hyperuricemia individuals US detects all elementary lesions of gout.
•	The future use of US in patients in the pre-clinical gout phase appears to be promising.

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Abstract

Ultrasound (US) is a recognized imaging modality for the assessment of gout. Recently it is being explored for its potential role in the evaluation of subjects with asymptomatic hyperuricemia (AH). Preliminary reports demonstrated the presence of monosodium urate (MSU)-crystal deposits including aggregates, double contour sign and/or tophi in both intra-articular and periarticular tissues of AH individuals. Although these results are exciting, the value and potential application of US in AH remain to be clearly delineated. In this systematic literature review, we aim to summarise the recent publications regarding the role of US in the assessment of AH. We analyzed possible application of US in the daily clinical practice and its future clinical and research potential in the evaluation of AH individuals.

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Keywords : Asymptomatic hyperuricemia, Ultrasound, Gout