Tetramethylpyrazine: A review on its mechanisms and functions - 27/05/22
Abstract |
Ligusticum chuanxiong Hort (known as Chuanxiong in China, CX) is one of the most widely used and long-standing medicinal herbs in China. Tetramethylpyrazine (TMP) is an alkaloid and one of the active components of CX. Over the past few decades, TMP has been proven to possess several pharmacological properties. It has been used to treat a variety of diseases with excellent therapeutic effects. Here, the pharmacological characteristics and molecular mechanism of TMP in recent years are reviewed, with an emphasis on the signal-regulation mechanism of TMP. This review shows that TMP has many physiological functions, including anti-oxidant, anti-inflammatory, and anti-apoptosis properties; autophagy regulation; vasodilation; angiogenesis regulation; mitochondrial damage suppression; endothelial protection; reduction of proliferation and migration of vascular smooth muscle cells; and neuroprotection. At present, TMP is used in treating cardiovascular, nervous, and digestive system conditions, cancer, and other conditions and has achieved good curative effects. The therapeutic mechanism of TMP involves multiple targets, multiple pathways, and bidirectional regulation. TMP is, thus, a promising drug with great research potential.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | Tetramethylpyrazine is an alkaloid and one of the active components of Ligusticum chuanxiong Hort. |
• | Tetramethylpyrazine has the characteristics of multiple targets and multiple pathways. |
• | Tetramethylpyrazine plays a role in various diseases, among which cardiovascular and cerebrovascular diseases are the most prominent. |
• | The most important functions of tetramethylpyrazine are anti-inflammatory and antioxidant. |
• | Tetramethylpyrazine has great potential and is worth exploring and researching. |
Abbreviations : CX, TMP, AS, PPARs, LXRs, ROS, SOD, CAT, SREBP, ox-LDL, SR-A, ABCA, ICAM-1, 5-LOX, TLRs, NLRP3, HUVECs, eNOS, VEGF, STAT3, HO-1, MI, SYP, ncRNA, PGC-1α, mPTP, ER, I/R, LPS, ERK, BBB, EpFAs, EETs, sEH, BSCB, CXCR4, MMP2/9, OA, AP, PD, DM, HSCs, AKI
Keywords : Tetramethylpyrazine, Ligusticum chuanxiong Hort, Pharmacology, Cardiovascular disease, Cerebrovascular disease
Plan
Vol 150
Article 113005- juin 2022 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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