Triglyceride–glucose index associates with incident heart failure: a cohort study - 01/06/22

Doi : 10.1016/j.diabet.2022.101365

Luli Xu ^1,^2,^{^{†
Luli Xu and Mingyang Wu contributed equally to this work}}, Mingyang Wu ^1,^2,^{^{†
Luli Xu and Mingyang Wu contributed equally to this work}}, Shuohua Chen ³, Yingping Yang ^1,², Youjie Wang ^1,², Shouling Wu ³ , Yaohua Tian ^1,^2,^⁎
¹ Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No.13 Hangkong Road, Wuhan 430030, China
² Ministry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No.13 Hangkong Road, Wuhan 430030, China
³ Department of Cardiology, Kailuan General Hospital, North China University of Science and Technology, No.57 Xinhua East Street, Tangshan 063000, China

^⁎Correspondence: Yaohua Tian, Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No.13 Hangkong Road, Wuhan, China, 430030, Tel.: +86-188-1133-2159Department of Maternal and Child HealthSchool of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyNo.13 Hangkong RoadWuhan430030China

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Abstract

Aims

Triglyceride–glucose (TyG) index has been proposed as a simple surrogate marker of insulin resistance. However, few studies have investigated the association of TyG index with heart failure (HF). We aimed to explore the relationship between TyG index and incident HF.

Methods

A total of 138,620 participants from the Kailuan study were included for analysis. TyG index was calculated as ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL) / 2]. Cox proportional hazard models were used to investigate the association between TyG index and the risk of HF. Restricted cubic spline analysis was applied to evaluate the dose-response relationship between TyG index and the risk of HF.

Results

There were 1602 incident HF cases among the 138,620 participants during a median follow-up of 8.78 years. Compared with those in the lowest quartile group of TyG index, participants with the highest quartile of TyG index had a 24% higher risk of HF (HR=1.24, 95%CI=1.07-1.44) after adjusting for other risk factors. Restricted cubic spline analysis showed a significant J-shaped dose-response relationship between TyG index and risk of HF (P for non-linearity < 0.001). The significant association was still observed among the men and participants with or without abdominal obesity in subgroup analyses.

Conclusion

The TyG index was positively associated with the risk of HF, which indicates that the TyG index might be useful to identify people at high-risk for developing HF.

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Keywords : Triglyceride glucose index, Heart failure, Insulin resistance, Cohort study