Patient-important outcomes in lung transplantation: A systematic review - 17/06/22
for the
Bichat Lung Transplant Program
Highlights |
• | Patient-important outcomes reflect how a patient feels, functions or survives. |
• | At least one of those is assessed in half of 2019 studies on lung transplantation. |
• | Mortality was the main patient-important outcome assessed, while non-mortality outcomes were insufficiently considered. |
• | A core outcome set in lung transplantation should be developed with patients’ input. |
Abstract |
Background |
Patient-important outcomes (PIOs) have emerged in respiratory medicine, in order to place the patient at the center of research. Mortality is a debated PIO in lung transplantation (LTx). The use of PIO in this specific setting has never been studied. We aimed to systematically review the use of PIOs in LTx research.
Methods |
MEDLINE, Cochrane Library and Embase databases were searched to include prospective studies published in 2019, involving adult LTx recipients. We excluded articles reporting non-prognostic studies, letters, reviews, commentaries, or case reports. PIOs considered were mortality, pain, physical function, pulmonary, gastrointestinal, neuropsychological, cardiac, sleep or sexual symptoms and quality of life. This systematic review was prospectively registered in the PROSPERO register (CRD42020163425).
Results |
Among 1048 references retrieved, 51 were finally included in the analysis. In total, 26 (51%) studies investigated at least one PIO, as a primary outcome in 12 (23.5%) and secondary outcome in 21 (41.2%). In 15 (29.4%) studies, mortality was the most frequently reported PIO; 11 (21.5%) studies evaluated at least one PIO other than mortality, quality of life being this PIO in 6.
Conclusions |
PIOs were described in half of prospective articles dealing with adult LTx recipients published in 2019. Outcomes other than mortality were insufficiently considered. A core outcome set of PIOs in LTx should be developed with patient input to guide future research in LTx.
Le texte complet de cet article est disponible en PDF.Keywords : Lung transplantation, Patient important outcomes, Systematic review
Abbreviations : 6MWD, CLAD, COPD, CRQ, HADS, IQR, LTx, MRC, PIO, PRISMA, PRO, PROM, SD, SF-36, SGRQ, SPPB
Plan
Vol 81
Article 100896- mai 2022 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?