Elizabethkingia anophelis outbreak in France - 30/07/22
, M.S. Fangous b, E. Le Breton b, c, M. Artus b, F. le Gall b, L. Khatchatourian a, J.P. Talarmin a, P. Plesiat d, e, K. Jeannot d, e, N. Saidani a, G. Rolland-Jacob cHighlights |
• | Elizabethkingia anophelis was responsible for a high mortality rate outbreak. |
• | A common environmental reservoir was suspected. |
• | Treatment can be difficult and no therapeutic guidelines are available to date. |
• | Co-trimoxazole and ciprofloxacin could be the best empirical antibiotic therapies. |
Abstract |
Objective |
We report an outbreak of Elizabethkingia anophelis infections in France. To the best of our knowledge, this is the first outbreak described in Europe.
Methods |
Each E. anophelis-positive microbiological sample was considered a case. All patients were hospitalized in an infectious diseases unit. Clinical, environmental, and microbiological investigations (MALDI-TOF mass spectrometry, PCR, E-test) were performed for each case.
Results |
Twenty cases were reported from September 2020 to September 2021, mainly community-acquired infections, responsible for nine deaths. The phylogenetic analysis showed a clonal origin and excluded nosocomial transmission. Despite the analysis of multiple environmental specimens, no source of contamination was identified. All strains were highly resistant to cefotaxime, ceftazidime, and imipenem.
Conclusions |
Clinicians and microbiologists should be aware of this multidrug-resistant bacterium, capable of causing severe infections. Most strains showed the lowest minimum inhibitory concentration values for cotrimoxazole and ciprofloxacin, making them the best choice for empirical antibiotic therapy.
Le texte complet de cet article est disponible en PDF.Keywords : Elizabethkingia anophelis, Multidrug resistance, Outbreaks, Whole genome sequencing
Plan
Vol 52 - N° 5
P. 299-303 - août 2022 Retour au numéro
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