When targeted therapy for cancer leads to ICU admission. RETRO-TARGETICU multicentric study - 30/08/22
Summary |
Purpose |
To study prevalence of targeted therapy (TT)-related adverse events requiring ICU admission in solid tumor patients.
Methods |
Retrospective multicenter study from the Nine-i research group. Adult patients who received TT for solid tumor within 3 months prior to ICU admission were included. Patients admitted for TT-related adverse event were compared to those admitted for other reasons.
Results |
In total, 140 patients, median age of 63 (52–69) years were included. Primary cancer site was mostly digestive (n=27, 19%), kidney (n=27, 19%), breast (n=24, 17%), and lung (n=20, 14%). Targeted therapy was anti-VEGF/VEGFR for 27% (n=38) patients, anti-EGFR for 22% (n=31) patients, anti-HER2 for 14% (n=20) patients and anti-BRAF for 9% (n=5) patients. ICU admission was related to TT adverse events for 30 (21%) patients. The most frequent complications were interstitial pneumonia (n=7), cardiac failure (n=5), anaphylaxis (n=4) and bleeding (n=4). At ICU admission, no significant difference was found between patients admitted for a TT-related adverse event and the other patients. One-month survival rate was higher in patients admitted for TT adverse event (OR=5.733 [2.031–16.182] P<0.001).
Conclusions |
Adverse events related to targeted therapy accounted for 20% of ICU admission in our population and carried a 16% one-month mortality. Outcome was associated with admission for TT related to adverse event, breast cancer and good performance status.
Le texte complet de cet article est disponible en PDF.Keywords : Solid tumours, ICU, Adverse event, Targeted therapy, Outcome
Plan
Vol 109 - N° 9
P. 916-924 - septembre 2022 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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