Among healthcare workers (HCWs) in France after the first COVID-19 wave, SARS-CoV-2 IgG rate was 1.06% [0.86%–1.27%].
Contact with HCWs or household members with COVID-19 was associated with IgG presence.
Total SARS-CoV-2 antibodies decreased between day 0 and day 90 and with anosmia or ageusia.
Total SARS-CoV-2 antibodies were higher in HCWs older than 50 years.
To estimate the SARS-CoV-2 IgG seroprevalence rate in healthcare workers (HCWs) from Western France after the first 2020 wave, its determinants and the kinetics of total SARS-CoV-2 antibodies.
Patients and methods
Overall, 9,453 HCWs responded to a self-questionnaire and underwent a lateral flow immunoassay to assess SARS-CoV-2 IgG presence. For 72 HCWs who tested positive, total anti-nucleocapsid antibodies were assessed at day 0, 30, and 90.
SARS-CoV-2 IgG seroprevalence rate was 1.06 % [0.86 %–1.27 %]. Factors associated with IgG presence were gender, performing upper respiratory tract samples, contact with HCWs or household members diagnosed with COVID-19. Total antibodies decreased between day 0 and day 90, with anosmia or ageusia, and were higher in HCWs older than 50 years.
We reported a low prevalence rate of IgG and identified several risk factors associated with its presence and persistence of total antibodies. Additional studies are needed to confirm these observations.Le texte complet de cet article est disponible en PDF.
Keywords : SARS-CoV-2, Seroprevalence survey, Occupational exposure, Health care workers