SARS-CoV-2 Infection and Increased Risk for Pediatric Stroke - 20/11/22
Cet article a été publié dans un numéro de la revue, cliquez ici pour y accéder
Abstract |
Background |
There is an increased risk of stroke in adults with severe acute respiratory syndrome coronavirus 2 (coronavirus disease 2019 [COVID-19]) infection, but whether there is a similar association with stroke in children is unclear. Our objective was to determine whether there is a correlation between COVID-19 infection, multisystem inflammatory syndrome in children (MIS-C), and pediatric ischemic stroke.
Methods |
This was a retrospective, population-based cohort analysis between March 1, 2020, and June 30, 2021, conducted at a children's hospital. Pediatric patients with a diagnosis of ischemic stroke were identified using ICD-10 diagnoses of ischemic stroke, cerebrovascular accident, or cerebral infarction.
Results |
We identified 16 patients, seven male and nine female, with ischemic stroke. Ages were 8 months to 17 years (median 11.5 years). More Asian (6%) and black (13%) patients had strokes compared with population prevalence (2% each, respectively). No patients had active COVID-19 infection. COVID-19 antibodies were identified in five of 11 patients tested (45%), of whom three were diagnosed with MIS-C. 82% of the strokes occurred between February and May 2021. The peak incidence was in February 2021, which was two months after peak incidence of pediatric cases of COVID-19 and one month after the peak of MIS-C cases.
Conclusions |
Our study suggests that prior COVID-19 infection, but not acute infection, is correlated with a risk for stroke in the pediatric population. The risk for stroke appears to be distinct from the risk for MIS-C.
Le texte complet de cet article est disponible en PDF.Keywords : Coronavirus, COVID-19, Pediatric, Ischemic, Stroke, MIS-C
Plan
Conflict of Interest Disclosures: The authors have no conflicts of interest relevant to this article to disclose. |
|
Funding: No funding to report. |
|
Contributors' Statement: Drs. Vielleux, Swartwood, Nguyen, and James and Ms. Barbeau collected data, carried out the analyses, and reviewed and revised the manuscript. Dr. Bonkowsky conceptualized and designed the study, coordinated and supervised data collection, and drafted the initial manuscript. All authors provided edits to the manuscript, approved the final manuscript as submitted, and agree to be accountable for all aspects of the work. |
Bienvenue sur EM-consulte, la référence des professionnels de santé.