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Preoperative intestinal microbiome and metabolome in elderly patients with delayed neurocognitive recovery - 24/11/22

Doi : 10.1016/j.accpm.2022.101140 
Hongyu Liu a, Xueqing Yin a, Jiaying Li a, Yan Cao b, Yanjie Wang b, Wenjing Mu c, Zipeng Zhuo c, Lu Chen a, Zhongjie Zhang a, Xutong Qu a, Changsong Wang c, , Zhaodi Zhang a,
a Department of Anaesthesiology, Harbin Medical University Cancer Hospital, Harbin, China 
b Department of Urology, Harbin Medical University Cancer Hospital, Harbin, China 
c Department of Critical Care Medicine, Harbin Medical University Cancer Hospital, Harbin, China 

Corresponding author at: Department of Anaesthesiology, Harbin Medical University Cancer Hospital, No. 150 Haping Rd., Nangang District, Harbin 150081, China.Department of AnaesthesiologyHarbin Medical University Cancer HospitalNo. 150 Haping Rd.Nangang DistrictHarbin150081China⁎⁎Corresponding author at: Department of Critical Care Medicine, Harbin Medical University Cancer Hospital, No. 150 Haping Rd., Nangang District, Harbin 150081, China.Department of Critical Care MedicineHarbin Medical University Cancer HospitalNo. 150 Haping Rd.Nangang DistrictHarbin150081China

Abstract

Background

Delayed neurocognitive recovery (dNCR) is a common complication of the central nervous system in elderly patients. Currently, it is not clear whether the occurrence of dNCR is associated with the intestinal microbiota and its related metabolites. This study investigated the preoperative intestinal microflora and faecal metabolites of dNCR patients.

Methods

Twenty-two elderly urological patients were divided into a dNCR group (D group) and a non-dNCR group (ND group) according to the postoperative Mini-Mental State Examination (MMSE) score on the first and third day after surgery. A postoperative MMSE score ≤ 2 points compared with the preoperative score was considered evidence of dNCR. We used a comprehensive method that combined 16S rRNA gene sequencing and untargeted metabolomics to study the preoperative intestinal microflora and faecal metabolites of the two groups, and conducted correlation analysis between them.

Results

Compared with the D group, the microbial community in the ND group was more abundant. At the family level, the ND group was significantly enriched in Lachnospiraceae, Peptostreptococcaceae and Muribaculaceae. At the genus level, the faecal microbiota of the ND group was differentially enriched in Agathobacter, Dorea, Fusicatenibacter, Coprococcus_2 and Romboutsia while that of the D group was differentially enriched in Anaerofilum. Untargeted metabolomics revealed significant differences in eight different metabolites between the two groups, including ribose, ethanol, leucine, maltose, pentadecanoic acid, malonic acid 1,3,4-dihydroxybenzoic acid and 3-hydroxypalmitic acid. In addition, differential metabolites were associated with the abundance of specific bacteria.

Conclusions

The occurrence of dNCR may be associated with the intestinal flora and its related metabolite composition of patients before surgery.

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Keywords : Delayed neurocognitive recovery (dNCR), Intestinal microbiome, Metabolomics, 16S rRNA, Elderly, Biomarker


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© 2022  Société française d'anesthésie et de réanimation (Sfar). Publié par Elsevier Masson SAS. Tous droits réservés.
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Vol 41 - N° 6

Article 101140- décembre 2022 Retour au numéro
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