We report a case series of four patients diagnosed with COVID-19-associated secondary sclerosing cholangitis (SSC), a recently described rare late complication of severe COVID-19. Following prolonged stays in the intensive care unit, these patients developed marked sustained cholestasis and jaundice despite clinical improvement. Cholangiography showed beaded appearance of intra-hepatic bile ducts and bile casts were removed in one patient. None of the patients reached normalization of liver enzymes and at least one progressed to liver cirrhosis (follow-up time of 11 to 16 months). COVID-19-associated SSC has a dismal prognosis with rapid progression to advanced chronic liver disease.Le texte complet de cet article est disponible en PDF.
Keywords : COVID-19, Secondary sclerosing cholangitis, Cholangiopathy, Case series
Abbreviations : (ALT), (ALP), (ANA), (AST), (cACLD), (CT), (COVID-19), (ERCP), (GGT), (H&E), (HBV), (ICU), (IMV), (MRCP), (PEEP), (SARS-CoV-2), (SSC), (SSC-CIP), (ULN)