Optic neuritis in lung adenocarcinoma: A challenging diagnosis - 29/11/22
, Mariana Brandao a, Ali Oullai b, Dan Engelman b, Nathalie Ghorra c, Tarik Daif d, Tom Buelens d, Anne-Pascale Meert bAbstract |
Optic neuritis with CRMP-5 IgG is a paraneoplastic inflammation of the optic nerve associated with lung cancer, mostly small-cell lung cancer. We present the case of a patient with lung adenocarcinoma who developed progressive bilateral visual loss a few months after immune-chemotherapy with pembrolizumab and after Covid-19 vaccination. Positive CRMP-5 IgG were detected in blood sample and complete work-up – including brain MRI - did not show any progression. High dose systemic corticoids were administered with transient improving, followed by intravenous immunoglobulins, methotrexate and rituximab but despite negativization of CRMP-5 IgG, the patient had a progressive visual loss.
Le texte complet de cet article est disponible en PDF.Keywords : Non-small cell lung cancer, Paraneoplastic syndrome, Optic neuritis, CRMP-5
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Vol 82
Article 100966- novembre 2022 Retour au numéro
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