Median effective dose of 0.2% ropivacaine for ultrasound-guided median nerve block in young children - 18/01/23
Abstract |
Objective |
To determine the median effective dose (ED50) and the 95% effective dose (ED95) of 0.2% ropivacaine for ultrasound-guided lower forearm median nerve block in paediatric patients.
Methods |
Eligible children were American Society of Anesthesiologists (ASA) status I–II scheduled to have elective open surgery for trigger thumb repair. Patients were stratified into two age groups: 1- to 3-year-olds and 3- to 6-year-olds. The ED50 was determined by Dixon’s up-and-down method. The first patient received an ultrasound-guided median nerve block by injection of 2 mL of 0.2% ropivacaine. Each subsequent patient’s dose was determined by the response of the previous patient, the doses being adjusted in intervals of 0.2 mL. In addition, the 95% effective dose (ED95) was obtained using a probit regression approach. The patients’ general condition, postoperative pain scores, and adverse events were recorded.
Results |
A total of 52 children who were scheduled to undergo open surgery for trigger thumb were included in this study: 28 in the 1- to 3-year-olds group and 24 in the 3- to 6-year-olds group. The ED50 (95% confidence interval) values were 0.9 (0.44–1.36) mL in 1- to 3-year-olds and 1.4 (1.14–1.66) mL in 3- to 6-year-olds. The ED95 (95% confidence interval) values were 1.5 (0.98–1.58) mL in 1- to 3-year-olds and 1.7 (1.54–1.78) mL in 3- to 6-year-olds. No adverse events occurred.
Conclusions |
A single dose of ropivacaine was an effective agent for young children requiring ultrasound-guided lower forearm median nerve block in open surgery for trigger thumb. The ED50 (95% confidence interval) values were 0.9 (0.44–1.36) mL in 1- to 3-year-olds and 1.4 (1.14–1.66) mL in 3- to 6-year-olds. The ED95 (95% confidence interval) values were 1.5 (0.98–1.58) mL in 1- to 3-year-olds and 1.7 (1.54–1.78) mL in 3- to 6-year-olds.
Le texte complet de cet article est disponible en PDF.Keywords : Nerve block, Ropivacaine, Child, Trigger thumb, ED50
Plan
Vol 42 - N° 1
Article 101159- février 2023 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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