Multiple mechanisms of curcumin targeting spinal cord injury - 03/02/23
Abstract |
Spinal cord injury (SCI) is an irreversible disease process with a high disability and mortality rate. After primary spinal cord injury, the secondary injury may occur in sequence, which is composed of ischemia and hypoxia, excitotoxicity, calcium overload, oxidative stress and inflammation, resulting in massive death of parenchymal cells in the injured area, followed by the formation of syringomyelia. Effectively curbing the process of secondary injury can promote nerve repair and improve functional prognosis. As the main active ingredient in turmeric, curcumin can play an important role in reducing inflammation and oxidation, protecting the neurons, and ultimately reducing spinal cord injury. This article reviews the effects of curcumin on the repair of nerve injury, with emphasis on the various mechanisms by which curcumin promotes the treatment of spinal cord injury.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | Secondary spinal cord injury is composed of multiple mechanisms and leads to further deterioration of neurological function. |
• | The application of tissue engineering has improved the bioavailability of curcumin. |
• | Curcumin acts as an anti-inflammatory, antioxidant, anti-apoptotic and neuroprotective agent in secondary spinal cord injury through multiple pathways. |
Keywords : Spinal Cord Injury, Curcumin, Neuroprotective Mechanisms
Plan
Vol 159
Article 114224- mars 2023 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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