Natural flavonoids alleviate glioblastoma multiforme by regulating long non-coding RNA - 28/03/23
Abstract |
Glioblastoma multiforme (GBM) is one of the most common primary malignant brain tumors in adults. Due to the poor prognosis of patients, the median survival time of GBM is often less than 1 year. Therefore, it is very necessary to find novel treatment options with a good prognosis for the treatment or prevention of GBM. In recent years, flavonoids are frequently used to treat cancer. It is a new attractive molecule that may achieve this promising treatment option. Flavonoids have been proved to have many biological functions, such as antioxidation, prevention of angiogenesis, anti-inflammation, inhibition of cancer cell proliferation, and protection of nerve cells. It has also shown the ability to regulate long non-coding RNA (LncRNA). Studies have confirmed that flavonoids can regulate epigenetic modification, transcription, and change microRNA (miRNA) expression of GBM through lncRNA at the gene level. It also found that flavonoids can induce apoptosis and autophagy of GBM cells by regulating lncRNA. Moreover, it can improve the metabolic abnormalities of GBM, interfere with the tumor microenvironment and related signaling pathways, and inhibit the angiogenesis of GBM cells. Eventually, flavonoids can block the tumor initiation, growth, proliferation, differentiation, invasion, and metastasis. In this review, we highlight the role of lncRNA in GBM cancer progression and the influence of flavonoids on lncRNA regulation. And emphasize their expected role in the prevention and treatment of GBM.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Flavonoids can directly act on glioblastoma multiforme to prevent its proliferation and invasion. |
• | Different flavonoids can act on many kinds of lncRNA. |
• | The regulation of lncRNA can also change the occurrence and development of glioblastoma multiforme from a variety of mechanisms. |
• | LncRNA can be used as a novel target for flavonoids to alleviate glioblastoma multiforme. |
• | It is a new trend to use natural medicine to treat cancer. |
Keywords : Natural flavonoids, Long non-coding RNA, Glioblastoma multiforme, Potential mechanism, Prevention, Treatment
Plan
Vol 161
Article 114477- mai 2023 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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