Variable Association of Physiologic Changes With Electrographic Seizure-Like Events in Infants Born Preterm - 28/03/23
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Abstract |
Objectives |
To determine the incidence of seizure-like events in a cohort of infants born preterm as well as the prevalence of associated vital sign changes (heart rate [HR], respiratory rate, and pulse oximetry [SpO2]).
Study design |
We performed prospective conventional video electroencephalogram monitoring on infants born at 23-30 weeks of gestational age during the first 4 postnatal days. For detected seizure-like events, simultaneously captured vital sign data were analyzed during the pre-event baseline and during the event. Significant vital sign changes were defined as HR or respiratory rate >±2 SD from the infant’s own baseline physiologic mean, derived from a 10-minute interval before the seizure-like event. Significant change in SpO2 was defined as oxygen desaturation during the event with a mean SpO2 <88%.
Results |
Our sample included 48 infants with median gestational age of 28 weeks (IQR 26-29) and birth weight of 1125 g (IQR 963-1265). Twelve (25%) infants had seizure-like discharges with a total of 201 events; 83% (10/12) of infants had vital sign changes during these events, and 50% (6/12) had significant vital sign changes during the majority of the seizure-like events. Concurrent HR changes occurred the most frequently.
Conclusions |
Individual infant variability was observed in the prevalence of concurrent vital sign changes with electroencephalographic seizure-like events. Physiologic changes associated with preterm electrographic seizure-like events should be investigated further as a potential biomarker to assess the clinical significance of such events in the preterm population.
Le texte complet de cet article est disponible en PDF.Keywords : premature, video EEG, vital signs
Abbreviations : cEEG, EEG, IVH
Plan
Supported by the Gerber Foundation (to A.M.) and the National Institutes of Health/National Notifiable Diseases Surveillance System K23 (NS111086 [to Z.V.]). Study sponsors did not have any role in study design; the collection, analysis, and interpretation of data; writing of the report; and the decision to submit the manuscript for publication. The authors declare no conflicts of interest. |
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Accepted for presentation, in abstract form, at the 2020 Pediatric Academic Societies meeting, which was to be held in May 2020 but was cancelled due to coronavirus disease-19 pandemic. |
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