Synergistic effect of docetaxel and gambogic acid on bone metastasis of lung cancer - 06/05/23

Doi : 10.1016/j.bulcan.2023.02.007

Siyan Zhang ^1,^2,^3,^4,^{^{5
These authors contributed equally to this work.}}, Xingyao Zhang ^1,^2,^3,^4,^{^{5
These authors contributed equally to this work.}}, Dong Zhang ^1,^2,^3,^4,^{^{5
These authors contributed equally to this work.}}, Liang Wei ^1,^2,^3,⁴, Bin Xiong ^1,^2,^3,⁴, Qi Meng ^1,^2,^3,⁴, Shougang Jiang ^1,^2,^3,^4,^⁎
¹ Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin, PR China
² State Engineering Laboratory of Bio-Resources Eco-Utilization, Northeast Forestry University, Harbin, PR China
³ College of Chemistry Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, PR China
⁴ Heilongjiang Provincial Key Laboratory of Ecological Utilization of Forestry-based Active Substances, Harbin, PR China

^⁎Shougang Jiang, Key Laboratory of Forest Plant Ecology, Northeast Forestry University, Hexing Road 26, 150040 Harbin, China.Key Laboratory of Forest Plant Ecology, Northeast Forestry UniversityHexing Road 26Harbin150040China

Summary

Introduction

Gambogic acid (GA) as an active compound isolated from Gamboge, have been investigated for many years and proved to be a promising natural anticancer agent for clinical treatment. This study aimed to investigate the inhibitory effect of docetaxel (DTX) combined with gambogic acid on bone metastasis of lung cancer.

Methods

The anti-proliferation effect of the combination of DTX and GA on Lewis lung cancer (LLC) cells was determined by MTT assays. The anticancer effect of the combination of DTX and GA on bone metastasis of lung cancer in vivo was explored. Evaluation of the efficacy of drug therapy was performed by comparing the degree of bone destruction and the pathological section of bone tissue of the treated mice with that of the control mice.

Results

In vitro cytotoxicity, cell migration, and osteoclast-induced formation assay showed that GA enhanced the therapeutic effect of DTX in Lewis lung cancer cell with a synergistic effect. In an orthotopic mouse model of bone metastasis, the average survival of the DTX+GA combination group (32.61d±1.06 d) was significantly increased compared with that of the DTX group (25.75 d±0.67 d) or GA group (23.99 d±0.58 d), *P<0.01.

Conclusion

The combination of DTX and GA has synergistic effect and resulted in more effective inhibition of tumor metastasis, providing a strong preclinical rationale for the clinical development of the DTX+GA combination for treating bone metastasis of lung cancer.

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Keywords : Lung cancer, Bone metastasis, Docetaxel, Gambogic acid, Combination therapy

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Vol 110 - N° 5

P. 478-486 - mai 2023 Retour au numéro

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Synergistic effect of docetaxel and gambogic acid on bone metastasis of lung cancer - 06/05/23

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