Natural history of focal nodular hyperplasia - 06/05/08
Valérie D'Halluin [1],
Valérie Vilgrain [2],
Gilles Pelletier [1],
Laurence Rocher [3],
Jacques Belghiti [4],
Serge Erlinger [5],
Catherine Buffet [1]
Voir les affiliationsAim |
To evaluate the natural course of focal nodular hyperplasia according to hormonal status.
Methods |
Forty-four patients were included in this retrospective study. Tumor size was assessed with ultrasound examination. We studied the influence of hormone status on the course of the disease.
Results |
All patients were women, the median age at diagnosis was 35 years and the median follow-up was 45 months. Ten patients were symptomatic at diagnosis, while none were symptomatic at the end of follow-up. The median size of the lesions was 56 mm. No complications occurred. The size of the tumor remained stable in 19 patients, increased in 12 and decreased in 13. Twenty-one of 37 patients stopped taking oral contraceptives at diagnosis: the lesion remained stable in 11 patients, increased in 3 and decreased in 7. Two patients didn't stop taking oral contraceptives: the lesion increased in one, decreased in the other. Six patients became pregnant and 6 patients went into menopause during follow-up: the lesion remained stable in 3 and 4 patients respectively.
Conclusion |
Focal nodular hyperplasia is a benign lesion. Tumor size remained stable in most cases. It seems that the hormonal status has little or no influence on the course of the disease.
Keywords:
Focal nodular hyperplasia
,
Benign tumor of the liver
,
Oral contraception
,
Pregnancy
Plan
© 2001 Elsevier Masson SAS. Tous droits réservés.
Vol 25 - N° 11
P. 1008-1010 - novembre 2001 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.