The epileptogenic potential of quinolones differs from one compound to another. The rare epileptic seizures induced by gatifloxacine have followed administration by the intravenous route.
This paper reports two aged women presenting with generalized status epilepticus after oral treatment with standard doses of gatifloxacine, who both recovered well. A past medical history of convulsions was the only significant factor found. Brain MRI was unremarkable. In one patient an EEG showed continuous bilateral paroxysmal discharges that were predominantly frontal.
Caution is needed when using quinolone antibiotics in elderly patients, especially in those with a past history of epilepsy.
© 2007 Elsevier Masson SAS. Tous droits réservés.