Oral semaglutide effectiveness and safety in real world practice; The REVOLUTION study - 09/03/24

Doi : 10.1016/j.deman.2024.100209

Abdulrahman Alsheikh ^a,^b, Ali Alshehri ^c, Saad Alzahrani ^c, Anwar AlJammah ^d,^e, Fahad Alqahtani ^f, Metib Alotaibi ^e,^g, Raed Aldahash ^h,^g, Amani M. Alhozali ^a,ⁱ, Fahad Alsabaan ^j, Mohammed Almehthel ^c, Naser Aljuhani ^k, Ali Aldabeis ^j, Moneer Alamri ^l, Waleed Maghawry ^m, Naweed Alzaman ^n,^o, Alshaima Alshaikh ^p, Omar M. Alnozha ^n,^q, Emad R Issak ^r,^⁎ , Saud Alsifri ^s
^a King Abdulaziz University Hospital, Jeddah, Saudi Arabia
^b Dr. Suliman Fakeeh Hospital, Jeddah, Saudi Arabia
^c King Fahad Medical city, Riyadh, Saudi Arabia
^d King Saud University Medical City, Riyadh, Saudi Arabia
^e Alhammadi Hospital, Riyadh, Saudi Arabia
^f Tadawi Medical Center, Abha, Saudi Arabia
^g Dr Suliman Alhabeeb Hospital, Alolya, Riyadh, Saudi Arabia
^h King Abdallah Medical City, National Guard, Riyadh, Saudi Arabia
ⁱ International Medical Center, Jeddah, Saudi Arabia
^j Security Forces Hospital, Riyadh, Saudi Arabia
^k East Jeddah Hospital, Jeddah, Saudi Arabia
^l Southern Armed Forces Hospital, Khamis Mushait, Saudi Arabia
^m Alnahda Polyclinic, Jeddah, Saudi Arabia
ⁿ Department of Medicine, College of Medicine, Taibah University, Madinah, Saudi Arabia
^o Madina Medical Center, Madinah, Saudi Arabia
^p King Abdallah Medical City, National Guard, Jeddah, Saudi Arabia
^q Saudi German Hospital, Madinah, Saudi Arabia
^r Department of Internal Medicine, Ain Shams University, Cairo, Egypt
^s Alhada Armed Forces Hospital, Taif, Saudi Arabia

^⁎Corresponding author: Mobile: +201066208065

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Abstract

Aims

This study seeks to provide insights into the practical application and effects of oral semaglutide in Saudi T2DM patients under routine medical supervision.

Methods

The primary outcome measure was the laboratory HbA1c. Secondary measures included fasting blood glucose (FBG), weight, and hypoglycemia. All variables were checked after six months and 12 months of initiation.

Results

The analysis of this study included 245 uncontrolled (HbA1c > 7 %) T2DM patients. The mean baseline HbA1c was 10.1 % (1.2). HbA1c was reduced by an average of 3.1 % (0.8) and 3.2 % (0.8) at 6 and 12 months, respectively. The frequency of hypoglycemia events in the last three months before semaglutide was initiated was 4.4 (1.1). The frequency of hypoglycemia events in the last three months was 2.2 (0.8) and 0.7 (0.4) at 6-month and 12-month follow-up visits, respectively. The percent reduction in body mass index (BMI) was an average of 13.0 % (1.4) and 19.7 % (3.4) at six months and 12 months, respectively. Lipid profile and blood pressure were improved at six months and 12 months.

Conclusions

Oral semaglutide provided substantial glycemic and weight-loss benefits in adult individuals with T2DM.

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Keywords : Semaglutide, Type 2 diabetes, Hba1c, Hypoglycemia, Weight reduction

Plan

Baseline characteristics

Follow-up: change in glycemic variables

Change in body weight and BMI

Change in other cardiometabolic parameters

Change in anti-DM medications

Discontinuation of semaglutide and adverse events

Discussion

Funding statement

CRediT authorship contribution statement

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Vol 14

Article 100209- avril 2024 Retour au numéro

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Oral semaglutide effectiveness and safety in real world practice; The REVOLUTION study - 09/03/24

Abstract

Aims

Methods

Results

Conclusions

Plan

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