Maintaining ideal cardiovascular health is associated with higher serum anti-aging protein klotho in the middle-aged and older populations - 01/04/24

Doi : 10.1016/j.jnha.2024.100224 
Kaisaierjiang Kadier a, 1, Pengfei Liu a, 1, Diliyaer Dilixiati b, 1, Xinliang Peng a, Aikeliyaer Ainiwaer c, Dinigeer Kadier d, Jiande Lu e, Xiaozhu Liu f, Mierxiati Ainiwan a, Qi Wang a, Xiang Ma a, , Yitong Ma a,
a Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China 
b Department of Urology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China 
c Department of Physiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht, Netherlands 
d Data Science and Business Analytics, Faculty of Economics and Business, University of Amsterdam, Amsterdam, Netherlands 
e Department of General Surgery, Children's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China 
f Department of Critical Care Medicine, Beijing Shijitan Hospital, Capital Medical University, Beijing, China 

Corresponding authors at: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Xinyi Road No. 393, Urumqi 830054, China.Department of CardiologyFirst Affiliated Hospital of Xinjiang Medical UniversityXinyi Road No. 393Urumqi830054China

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Abstract

Objectives

Maintaining ideal cardiovascular health (CVH) is believed to have potential anti-aging benefits. The American Heart Association (AHA) recently updated the "Life's Essential 8 (LE8)" Metrics to measure ideal CVH, but its connection with the anti-aging protein klotho is still unclear. We aimed to explore the relationship between ideal cardiovascular health and serum anti-aging protein klotho in a nationally representative US middle-aged and older population.

Design

A cross-sectional study.

Setting

The National Health and Nutrition Examination Survey (2007-2016).

Participants

A total of 9,457 middle-aged and older participants.

Measurements

Ideal CVH scores and their components were defined according to the guidelines set by the AHA. Serum klotho detected by enzyme-linked immunosorbent assay. Weighted multiple linear regression and restricted cubic spline were employed to examine the association between CVH score and klotho. Subgroup analyses were conducted, stratified by age (40-59 and 60-79), sex (Male and Female), race (Mexican American, non-Hispanic White, non-Hispanic Black, and Others) and chronic kidney disease (Yes and No) in fully adjusted models.

Results

A total of 9,457 middle-aged and older participants were included in this study, with a mean age of 55.27 ± 0.17. The mean serum klotho level in the population was 849.33 ± 5.39 pg/ml. After controlling for potential confounders, the LE8 scores showed a positive correlation with serum klotho levels (β: 1.32; 95% CI 0.73, 1.91), and a non-linear dose-response relationship was observed. Furthermore, we also discovered a positive relationship between health behavior scores and health factor scores and serum klotho levels (β: 0.48; 95% CI 0.07, 0.88 and β: 1.05; 95% CI 0.54, 1.56, respectively), particularly a stronger correlation between health factors and serum klotho. In the subgroup analysis, we observed a significant interaction between LE8 score and sex and race. (P for interaction <0.05).

Conclusions

LE8 and its subscale scores were positively associated with serum klotho levels in the middle-aged and older populations. Promoting the maintenance of ideal CVH can contribute to delaying the aging process.

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Abbreviations : CVH, AHA, LE8, CVD, NHANES, BMI, HEI-2015, PIR, HCVD, CKD, SD, CI, RCS

Keywords : Cardiovascular Health, Life’s Essential 8, Klotho, Biomarker of aging, NHANES



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