Unmet needs and knowledge gaps in aortic stenosis: A position paper from the Heart Valve Council of the French Society of Cardiology - 01/10/24

Doi : 10.1016/j.acvd.2024.06.004

Charles Fauvel ^a, Augustin Coisne ^b, Romain Capoulade ^c, Corentin Bourg ^d, Christelle Diakov ^e, Sophie Ribeyrolles ^e, Jérome Jouan ^f, Thierry Folliguet ^g, Marion Kibler ^h, Julien Dreyfus ⁱ, Julien Magne ^j,ⁿ, Yohann Bohbot ^k, Théo Pezel ^l, Thomas Modine ^m, Erwan Donal ^d,⁎
^a Cardiology Department, Rouen University Hospital, 76000 Rouen, France
^b Institut Pasteur de Lille, CHU Lille, Lille University, INSERM, 59000 Lille, France
^c L’Institut du Thorax, CHU Nantes, Nantes University, CNRS, INSERM, 44007 Nantes, France
^d Department of Cardiology, CHU Rennes, University of Rennes, INSERM, LTSI - UMR 1099, 35000 Rennes, France
^e Institut Mutualiste Montsouris, 75014 Paris, France
^f Department of Cardiac and Thoracic Surgery, Limoges University Teaching Hospital, 87000 Limoges, France
^g Department of Cardiac Surgery, Henri Mondor University Hospital, AP-HP, 94000 Créteil, France
^h Department of Cardiovascular Surgery and Medicine, New Civil Hospital, CHU Strasbourg, Strasbourg University, 67000 Strasbourg, France
ⁱ Cardiology Department, Centre Cardiologique du Nord, 93200 Saint-Denis, France
^j Department of Cardiology, Dupuytren Hospital, CHU Limoges, 87000 Limoges, France
^k Department of Cardiology, Amiens University Hospital, 80054 Amiens, France
^l Department of Radiology and Department of Cardiology, Lariboisière Hospital, AP–HP, Paris Cité University, 75010 Paris, France
^m Department of Cardiology and Cardiovascular Surgery, Haut-Lévêque Cardiological Hospital, Bordeaux University Hospital, 33604 Pessac, France
ⁿ INSERM 1094, Limoges Faculty of Medicine, 87025 Limoges, France

^⁎Corresponding author. Cardiology Department, Rennes University Hospital, rue Henri Le Guillou, 35000 Rennes, France.Cardiology Department, Rennes University Hospitalrue Henri Le GuillouRennes35000France

Sous presse. Épreuves corrigées par l'auteur. Disponible en ligne depuis le Tuesday 01 October 2024

Graphical abstract

Le texte complet de cet article est disponible en PDF.

Highlights

•	Aortic stenosis is the most common valvular heart disease in Western countries.
•	Despite advances, there are still knowledge gaps.
•	Gaps: pathophysiology; severity assessment; management; decision-making strategy.

Le texte complet de cet article est disponible en PDF.

Abstract

Nowadays, valvular heart disease remains a significant challenge among cardiovascular diseases, affecting millions of people worldwide and exerting substantial pressure on healthcare systems. Within the spectrum of valvular heart disease, aortic stenosis is the most common valvular lesion in developed countries. Despite notable advances in understanding its pathophysiological processes, improved cardiovascular imaging techniques and expanding therapeutic options in recent years, there are still unmet needs and knowledge gaps regarding aortic stenosis pathophysiology, severity assessment, management and decision-making strategy. This review, prepared on behalf of the Heart Valve Council of the French Society of Cardiology, describes these gaps and future research perspectives to improve the outcome of patients with aortic stenosis.

Le texte complet de cet article est disponible en PDF.

Keywords : Aortic stenosis, Prognosis, Epidemiology, Surgery, Transcatheter aortic valve implantation