The cardioprotective effects of Fruitflow® against Doxorubicin-induced toxicity in rat cardiomyoblast cells H9c2 (2−1) and high-fat diet-induced dyslipidemia and pathological alteration in cardiac tissue of Wistar Albino rats - 08/11/24
, Surajit Pathak a, ⁎ Abstract |
Background |
Natural compounds offer promising targets for cardioprotection, which could lead to enhanced clinical outcomes. We aimed to determine the cardioprotective effects of Fruitflow®, a water-soluble tomato extract known for its anti-platelet effects in doxorubicin-induced toxicity in rat cardiomyoblast cell line pathological alteration in heart tissue of high fat-fed Wistar Albino rats.
Methods |
The cardioprotective effect of Fruitflow® was investigated using H9c2 (2−1) cells (rat cardiomyoblast cell line) and high-fat diet-fed Wistar Albino rats. We evaluated morphological changes, cell proliferation, cell migration, antioxidant activity, cell cycle progression, and mitochondrial membrane potential after the Fruitflow® treatment in the Doxorubicin-injured H9c2 (2−1) cell line. We studied lipid profiles, inflammation, oxidative stress, and cardiac function regulatory enzyme activity in the rat model.
Results |
Fruitflow® dose-dependently stimulated cell proliferation and migration in Doxorubicin-injured H9c2 (2−1) cells, potentially promoting cardiac regeneration and supporting tissue repair. Fruitflow® modulated the cell cycle, improved mitochondrial function, and reduced oxidative stress. Furthermore, it significantly improved lipid profiles and enzyme activities and reduced inflammation and oxidative stress in high-fat-fed rats. Fruitflow® also modulated the expression of genes involved in cardiac remodeling, mitochondrial biogenesis, inflammation, and vascular function.
Conclusion |
Our findings suggest Fruitflow® may have cardioprotective effects, making it a potential treatment option for cardiac ailments. Larger-scale clinical trials were recommended further to determine the efficacy and safety of Fruitflow® as a potential therapeutic agent for cardiac diseases, potentially in combination with other cardioprotective medications.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Fruitflow® inhibits doxorubicin-induced cardiotoxicity in cardiomyoblasts and high-fat diet-induced dysfunction in rats. Created in BioRender. Duttaroy, A. (2024) BioRender.com/m12l525
Fruitflow® inhibits doxorubicin-induced cardiotoxicity in cardiomyoblasts and high-fat diet-induced dysfunction in rats. Created in BioRender. Duttaroy, A. (2024) BioRender.com/m12l525 Le texte complet de cet article est disponible en PDF.
Highlights |
• | Fruitflow promotes cardiomyoblast proliferation, cycle progression, and migration in doxorubicin-induced H9c2 (2−1) cells. |
• | Fruitflow reduces the Oxidative Stress and inflammation on H9c2 (2−1) cells and high-fat diet-fed Wistar albino rats. |
• | Fruitflow positively regulates key cardiac gene expression, promoting cardiac remodeling and fibrosis-like phenotype. |
Keywords : Doxorubicin, H9c2 (2-1) cells, High-fat diet, Cardiotoxicity, Fruitflow®
Plan
Vol 180
Article 117607- novembre 2024 Retour au numéro
Article précédent
- Oleocanthal mitigates CoCl2-induced oxidative damage and apoptosis via regulating MAPK pathway in human retinal pigment epithelial cells
- Ko-Chieh Huang, Yi-Fen Chiang, Mohamed Ali, Shih-Min Hsia
- Gilteritinib reverses ABCB1-mediated multidrug resistance: Preclinical in vitro and animal investigations
- Meng Zhang, Mei-Ling She, Jun Chen, Xiao-Qi Zeng, Qing-Quan Xiong, Ying-Huan Cen, Jia-An Ye, Guo-Bin Qiu, Shu-Yi Yang, Guang-Hui Ren
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?