Peripheral blood leukocyte telomere length is associated with age but not renal function: A cross-sectional follow-up study - 06/12/24

Doi : 10.1007/s12603-017-0905-4

Wei-Guang Zhang ^1,^{*
Wei-Guang Zhang and Linpei Jia contributed equally as the first authors.}, Linpei Jia ^1,^2,^{*
Wei-Guang Zhang and Linpei Jia contributed equally as the first authors.}, J. Ma ^3,^{*
Wei-Guang Zhang and Linpei Jia contributed equally as the first authors.}, S.-Y. Zhu ^4,^{*
Wei-Guang Zhang and Linpei Jia contributed equally as the first authors.}, S.-S. Nie ^1,^{*
Wei-Guang Zhang and Linpei Jia contributed equally as the first authors.}, K.-K. Song ^1,^{*
Wei-Guang Zhang and Linpei Jia contributed equally as the first authors.}, X.-M. Liu ^1,^{*
Wei-Guang Zhang and Linpei Jia contributed equally as the first authors.}, Y.-P. Zhang ^1,^{*
Wei-Guang Zhang and Linpei Jia contributed equally as the first authors.}, D. Cao ^1,^{*
Wei-Guang Zhang and Linpei Jia contributed equally as the first authors.}, X.-P. Yang ^5,^{*
Wei-Guang Zhang and Linpei Jia contributed equally as the first authors.}, D.-L. Zhao ^1,^{*
Wei-Guang Zhang and Linpei Jia contributed equally as the first authors.}, M.-J. Xiu ^1,^{*
Wei-Guang Zhang and Linpei Jia contributed equally as the first authors.}, L. Lin ^1,^{*
Wei-Guang Zhang and Linpei Jia contributed equally as the first authors.}, Z.-X. Li ^1,^{*
Wei-Guang Zhang and Linpei Jia contributed equally as the first authors.}, Q. Huang ^1,^{*
Wei-Guang Zhang and Linpei Jia contributed equally as the first authors.}, X.-Z. Chen ^1,^{*
Wei-Guang Zhang and Linpei Jia contributed equally as the first authors.}, L. Chen ^1,^{*
Wei-Guang Zhang and Linpei Jia contributed equally as the first authors.}, P. Wang ^1,^{*
Wei-Guang Zhang and Linpei Jia contributed equally as the first authors.}, X.-J. Bai ^6,^{*
Wei-Guang Zhang and Linpei Jia contributed equally as the first authors.}, Z. Feng ^1,^{*
Wei-Guang Zhang and Linpei Jia contributed equally as the first authors.}, B. Fu ^1,^{*
Wei-Guang Zhang and Linpei Jia contributed equally as the first authors.}, J. Huang ^1,^{*
Wei-Guang Zhang and Linpei Jia contributed equally as the first authors.}, J.-P. Zhang ^1,^{*
Wei-Guang Zhang and Linpei Jia contributed equally as the first authors.}, Guangyan Cai ^1,^{*
Wei-Guang Zhang and Linpei Jia contributed equally as the first authors.}, X.-F. Sun ^1,^{*
Wei-Guang Zhang and Linpei Jia contributed equally as the first authors.}, Xiangmei Chen ^1,^{*
Wei-Guang Zhang and Linpei Jia contributed equally as the first authors.}
¹ Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, 28 Fuxing Road, 100853, Beijing, China
² Department of Nephrology, The Second Hospital of Jilin University, Changchun, Jilin, China
³ Department of Nephrology, Zhumadian Central Hospital, Zhumadian, Henan, China
⁴ Department of Nephrology, The Second Affiliated Hospital of Nanchang Medical University, Nanchang, China
⁵ Department of Hematology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, China
⁶ Department of Geriatrics, Shengjing Hospital of China Medical University, Shenyang, China

connectez-vous ou créez un compte

Bienvenue sur EM-consulte, la référence des professionnels de santé.
Article gratuit.

Connectez-vous pour en bénéficier!

Abstract

Objectives

We aimed to evaluate the relationship between baseline renal function and changes in telomere length in Han Chinese.

Methods

The telomere restriction fragment (TRF) length of leukocytes in the peripheral blood was measured in healthy volunteers recruited in 2014. The estimated glomerular filtration rate (eGFR) was calculated based on serum creatinine (Scr) and serum cystatin C (CysC)-eGFRcys and eGFRScr-cys through the Cockcroft-Gault formula (eGFRC-G) or the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI / eGFRCKD-EPI) equation. The correlation between telomere length changes over time and renal function was analyzed.

Results

Leukocyte TRF lengths were negatively correlated to age (r = -0.393, p < 0.001) and serum CysC (r = -0.180, p < 0.01), while positively associated with eGFRCKD-EPI, eGFRC-G, eGFRcys, and eGFRScr-cys (r = 0.182, 0.122, 0.290, and 0.254 respectively, p < 0.01). The 3-year change of telomere length was 46 bp/years. When adjusted for age, the associations between telomere length changes and baseline, subsequent TRF lengths, and serum CysC were no longer present. No association was observed between TRF length changes and renal function.

Conclusion

The rate of telomere length changes was affected by age and baseline telomere length. The telomere length changes might be important markers for aging.

Le texte complet de cet article est disponible en PDF.

Key words : Telomere length, renal function, aging, cystatin C

Plan

Introduction

Materials and Methods

Sample screening

Clinical and biochemical parameter examined

Determination of telomere restriction fragment (TRF) length

Statistical analysis

Result

Discussion

Export

Vol 22 - N° 2

P. 276-281 - février 2018 Retour au numéro

Article précédent

Single-arm resistance training study to determine the relationship between training outcomes and muscle growth factor mRNAs in older adults consuming numerous medications and supplements
Richard A. Dennis, K.K. Garner, P.M. Kortebein, C.M. Parkes, M.M. Bopp, S. Li, K.P. Padala, P.R. Padala, D.H. Sullivan

| Article suivant

The impact of dietary factors on indices of chronic disease in older people: A systematic review
Caryl A. Nowson, C. Service, J. Appleton, J.A. Grieger

Bienvenue sur EM-consulte, la référence des professionnels de santé.

connectez-vous ou créez un compte

Peripheral blood leukocyte telomere length is associated with age but not renal function: A cross-sectional follow-up study - 06/12/24

Abstract

Objectives

Methods

Results

Conclusion

Plan

Export citations

Fichier

Contenu

Accès rapides

Mon compte

Aide & support

Plateformes Elsevier Masson

Déclaration CNIL