Distribution of beta-lactamase genes in Enterobacteriaceae from human clinical samples - 06/02/25
, Babafela Awosile ⁎ Highlights |
• | Significant distribution of beta-lactamase genes in human clinical samples from 83 countries. |
• | Highest proportion of beta-lactamase found in Klebsiella spp., Escherichia coli, and Proteus spp. |
• | The ESBL gene blaCTX-M-15 was most prevalent in Klebsiella spp. and E. coli. |
• | blaNDM-1, blaOXA-48, and blaKPC-2 genes were common in Providencia spp., Raoultella spp., Serratia spp., and Klebsiella spp. |
Abstract |
Background |
This study aimed to explore the distribution of beta-lactamase genes in Enterobacteriaceae from human clinical samples.
Methods |
We analyzed data from 83 countries through the Antimicrobial Testing Leadership and Surveillance program, spanning 2004 to 2021. We calculated the proportion of each β-lactamase gene across nine bacterial species and generated a heatmap for β-lactamase genes with a frequency of ≥ 1 % in at least one species.
Results |
A total of 359 β-lactamase genes were identified, with the highest proportion found in Klebsiella spp. (61.84 %, n = 222), followed by Escherichiacoli (47.63 %, n = 171), and Proteus spp. (20.61 %, n = 74). The ESBL gene blaCTX-M−15 was most prevalent in Klebsiella spp. (62.39 %) and E.coli (53.16 %). The carbapenemase genes blaNDM-1, blaOXA-48, and blaKPC-2 were notably higher in Providencia spp. (59.47 %), Raoultella spp. (45.45 %), and Serratia spp. (25.24 %), respectively.
Conclusion |
Further surveillance and research are needed to investigate the diversity of β-lactamase genes across One Health interfaces.
Le texte complet de cet article est disponible en PDF.Keywords : Beta-lactamase genes, blaCTX-M−15, blaNDM-1, Distribution, Enterobacteriaceae
Plan
Vol 55 - N° 1
Article 105019- février 2025 Retour au numéro
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