Efficacy and safety of pharmacological treatments for gestational diabetes: a systematic review comparing metformin with glibenclamide and insulin - 13/02/25

Doi : 10.1016/j.diabet.2025.101622

Louise Bodier ^a, Maela Le Lous ^a, Hélène Isly ^a, Christèle Derrien ^b, Patricia Vaduva ^b,^⁎
^a Department of Gynecology and Obstetrics, Rennes University Hospital, France
^b Department of Endocrinology – Diabetes – Nutrition, Rennes University Hospital, France

^⁎Correspondence author at Department of Endocrinology – Diabetes – Nutrition, Rennes University Hospital, 16 Boulevard de Bulgarie, 35200 Rennes, France.Department of Endocrinology – Diabetes – NutritionRennes University Hospital16 Boulevard de BulgarieRennes35200France

Highlights

•	Metformin is a harmless and effective treatment for gestational diabetes mellitus, providing good glycemic control.
•	Metformin is linked to a decrease in maternal weight gain, a lower risk of hypertensive complications, and reduced incidence of maternal and neonatal hypoglycemia.
•	Metformin may reduce the risk of macrosomia compared to other treatments like Insulin.
•	While glibenclamide is as effective as insulin for glycemic control, it carries a higher risk of neonatal hypoglycemia.

Le texte complet de cet article est disponible en PDF.

Abstract

Aim

Gestational diabetes, characterized by impaired glucose tolerance occurring or diagnosed during pregnancy, is a significant public health concern. When lifestyle and dietary measures fail (30 % of women), insulin is the standard treatment. Oral antidiabetic agents, such as metformin (Glucophage) and glibenclamide, could provide a promising alternative. The aim here was to evaluate the effectiveness and safety of these treatments in gestational diabetes.

Methods

This study is based on a systematic literature review. A keyword search for "metformin (Glucophage)," "glibenclamide," "pregnancy," and "gestational diabetes" was conducted in the PubMed and Google Scholar databases from 2013 to 2023.

Results

A total of 45 studies were selected and analyzed. metformin (Glucophage) appears to offer a combination of effectiveness in glycemic control and maternal and neonatal safety. Compared to insulin, it reduces maternal weight gain, lowers maternal hypoglycemia rates, and shows a tendency to reduce gestational hypertension and preeclampsia. Additionally, infants born to mothers on metformin (Glucophage) are less likely to be macrosomic, experience fewer neonatal hypoglycemic episodes, and require fewer admissions to intensive care units. On the other hand, glibenclamide seems effective in glycemic control but is associated with higher rates of macrosomia and neonatal hypoglycemia.

Conclusion

Metformin (Glucophage) appears to be a promising alternative to insulin for treating gestational diabetes, while uncertainties remain regarding the safety of glibenclamide.

Le texte complet de cet article est disponible en PDF.

Keywords : Gestational diabetes mellitus, Glibenclamide, Insulin, Metformin, Treatments