The randomized trial by Muraleedharan et al. explored the optimal duration of platelet concentrate storage, concluding that storage duration has no clinical relevance. While the study provides novel insights, we identified two methodological concerns. First, the sample size estimation was based on local transfusion needs rather than a broader population, potentially affecting effect estimation and generalizability. Additionally, the study’s inclusion of intensive care unit (ICU) patients may introduce heterogeneity that is not accounted for in a small study population. Second, the absence of clear criteria for platelet transfusion, coupled with the non-blinded study design, raises concerns about potential bias in treatment decisions. Addressing these limitations in future research will improve the validity and applicability of findings.