Sexual dysfunctions appear in schizophrenic patients at the onset of the disorder. However, the intensity of these dysfunctions increases following long-term antipsychotic treatment.

The examination of various aspects of sexuality in chronic female schizophrenic patients and the evaluation of sexual side effects of conventional and atypical antipsychotics.

50 female patients suffering from chronic schizophrenia were selected and treated with conventional and atypical antipsychotics. These patients were compared to 50 matched controls. The means of assessment consisted of the use of the following: PANSS, UKU sexual side effects component, GAF, female SDBQ, WHOQOL-BREF.

The patients examined displayed a range of characteristics. These include hyposexuality and dissatisfaction with their sexual life. Many had also experienced sexual abuse, and few used contraception, thus indicating a high level of sexual conservatism. The evolution of schizophrenia affected their professional and marital status, as well as their general level of functioning and their quality of life.

It was found that even novel antipsychotics are responsible for sexual side effects comparable to those produced by conventional antipsychotics.

This direct investigation of sexuality in this particular group, could, in combination with the management of information, symptoms, and side effects, lead to long term acceptance of - and adherence to - antipsychotic medication by sexually active persons suffering from schizophrenia. The overall quality of life of these individuals, as well as their general functioning, could thus be improved.