T09-P-04 Efficacy of ED treatment with PDE5-inhibitors in the Italian real clinical practice contest: longitudinal data from the EDOS study - 27/06/08
Résumé |
EDOS is an observational perspective study enrolling patients affected by Erectile Dysfunction wishing to receive a treatment. The study has been performed in the real clinical practice contest, and clinicians were free to prescribe any therapy for ED and to change therapy in each moment. A significative percentage of patients continue to assume the starting treatment. These subgroups allow a comparison analysis about efficacy of the different treatments employed.
1419 men, that spontaneously asked to their GP or to a specialist to start a treatment for ED or to change their ongoing therapy, were enrolled; 714 completed the 6months therapy assuming the baseline prescribed drug, in a continuous way: Tadalafil (n=535), Sildenafil (n=75), Vardenafil (n=66), other drugs or non pharmacological treatment(n=38). Efficacy was assessed by the IIEF-Questions 6,7,14; time concerns’ domains, spontaneous behavior and self-confidence of SFPAIRS; EDITS-Question1; SI-Questions 1,2; GAQ1,2.
Patients reported the longer gap between drugʼs assumption and the moment in which they could start their intercourse. To compare the treatment groups,a multivariate analysis adjusted to the basal differences has been used. In terms of patientʼs efficacy,satisfaction,self confidence and spontaneous behavior, there are no statistically significant differences.
The time concerns domain of the SF-PAIRS is highly improved in Tadalafil: the gap elapsed between assuming drug and the intercourse was 21.4hours with Tadalafil, 6.6hours with Sildenafil and 7.7hours with Vardenafil.
The present observational study confirms that the PDE5-Is having no real differences in terms of efficacy. Tadalafil is, however, characterized for its lasting efficacy that determines a better impact concerning the anxiety of planning an intercourse and completing it before the drugʼs time of action is over.
Le texte complet de cet article est disponible en PDF.Vol 17 - N° S1
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