Outcomes of Stereotactic Radiosurgery for Jugular Foramen Schwannomas: A Systematic Review and Meta-Analysis - 24/09/25
, Salem M. Tos a, 1, Ibrahim Mohammadzadeh b, Dorsa Najari c, Azin Ebrahimi c, Ehsan Bahrami Hezaveh c, Fatemeh Ghorbanpouryami c, Mohammad Amin Habibi dHighlights |
• | SRS for JFS achieves a high local control rate of 94% and a 10-year PFS of 84%. |
• | SRS offers a safer alternative to surgery, particularly for small- to medium-sized lesions without mass effect or brainstem compression. |
• | Surgery remains preferred for larger lesions requiring decompression or histological diagnosis, despite higher cranial nerve morbidity. |
Abstract |
Background |
Jugular foramen schwannomas (JFS) are infrequent cranial nerve (CN) lesions accounting for up to 4% of intracranial schwannomas. The management of the JFS is challenging due to its proximity to critical neurovascular structures. Stereotactic radiosurgery (SRS) has emerged as a minimally invasive alternative to resection; however, the available data regarding the outcomes of SRS in JFS is limited. This study aims to evaluate the role of SRS in JFS.
Methods |
A systematic search of PubMed, Embase, Scopus, and Web of Science was performed following PRISMA guidelines. Pooled estimates for local control (LC), cranial nerve (CN) deterioration, progression-free survival (PFS), and adverse radiation effects (ARE) were calculated using the R program.
Results |
Seventeen studies with 529 patients were included. The pooled LC rate was 94% (95% CI: 91%–96%), with a CN deterioration rate of 9% (95% CI: 3%–16%). The pooled 1-year PFS rate was 98% (95% CI: 96%–100%), 3-year PFS rate was 95% (95% CI: 92–97%, 5-year PFS rate was 92% (95% CI: 88–95%), and 10-year PFS rate was 84% (95% CI: 76–90%). The pooled ARE rate was 6% (95% CI: 2–11%).
Conclusion |
SRS results in promising LC and PFS rates along with low CN deterioration and ARE rates in JFS patients. Surgery remains the primary choice for those with larger lesions or mass-related symptoms, while SRS can be the first-line option for small to medium-sized lesions.
Le texte complet de cet article est disponible en PDF.Keywords : Stereotactic radiosurgery, Jugular Foramen Schwannoma, Cranial nerve schwannoma, Local control, Meta-analysis
Plan
Vol 71 - N° 6
Article 101725- novembre 2025 Retour au numéro
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