Adherent-Invasive E. coli (AIEC) in Crohn’s disease: where are we in 2025? Tribute to Professor Nicolas Barnich - 04/11/25
Doi : 10.1016/j.clinre.2025.102727
Anthony BUISSON 1, 2, ⁎ 
, Jérémy DENIZOT 2
, Jérémy DENIZOT 2 1 Service d'Hépato-Gastro Entérologie, Université Clermont Auvergne, Inserm, CHU Clermont-Ferrand, 3iHP, Clermont-Ferrand, France
2 Université Clermont Auvergne, Inserm U1071, USC-INRAE 2018, Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte (M2iSH), Clermont-Ferrand, 63001, France
⁎Corresponding author: Anthony BUISSON, University Hospital Estaing, Gastroenterology Department, 1 place Aubrac, 63100 Clermont-Ferrand, France. Phone: +33 4 73 750 523; Fax: +33 4 73 750 524.University Hospital Estaing, Gastroenterology Department1 place AubracClermont-Ferrand63100France
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Disponible en ligne depuis le Tuesday 04 November 2025
Highlights |
• | Minireview 3 |
• | Adherent Invasive Escherichia coli (AIEC) bacteria, which association with CD is worldwide well established, was discovered by Arlette Darfeuille-Michaud and her team in Clermont-Ferrand 25 years ago. |
• | AIEC interact with epithelial and immune cells and intestinal immune responses, thus suggesting AIEC targeting could be a relevant option in some patients with CD. |
• | In a proof-of-concept randomized controlled trial comparing the combination of two antibiotics versus placebo in CD patients colonized by AIEC, antibiotics failed to induce endoscopic response as compared to placebo. |
Plan
© 2025
Publié par Elsevier Masson SAS.
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