The association between medication use and lifestyle factors in independently living older people: impact of Mediterranean diet and physical activity - 08/11/25
, Greg Kennedy a, Denny Meyer a, Michael Kingsley d, e, Catherine Itsiopoulos h, Leonie Segal i, Anne-Marie Minihane f, Karen J Murphy g, Tuan Anh Nguyen j, k, l, Jeffery M Reddan a, Joris C Verster a, b, m, Andrew Pipingas a
Bienvenue sur EM-consulte, la référence des professionnels de santé.
Article gratuit.
Connectez-vous pour en bénéficier!
Highlights |
• | Moderate and high PA are linked to lower odds of polypharmacy in independently living older people. |
• | High PA is associated with fewer total medicatios and reduced cardiovascular drug use. |
• | Higher MedDiet scores are linked to reduced use of alimentary tract and metabolism medications. |
• | Encouraging a healthy lifestyle through PA or closely following a MedDiet might help reduce the development of chronic diseases and medication use in older adults. |
Abstract |
Objectives |
Adherence to the Mediterranean diet (MedDiet) and engagement in physical activity (PA) are associated with a lower risk of chronic disease, yet their relationship with medication use in older adults is less clear. This study examined cross-sectional associations between MedDiet adherence, PA levels, and medication use, including polypharmacy, in independently living older Australians.
Design |
A cross-sectional observational study
Setting and participants |
Baseline data were drawn from the MedWalk trial, including 161 participants (119 females, 42 males; aged 60–90 years) residing in independent living facilities in Adelaide and Melbourne, and the wider Melbourne community.
Measurements |
Adherence to the MedDiet was assessed using the 14-item Mediterranean Diet Adherence Screener (MEDAS). PA was objectively measured via accelerometry and categorized as low (<150 min/week), moderate (150–<300 min/week), or high (≥300 min/week) of moderate-to-vigorous PA. Medication use was self-reported and coded using Anatomical Therapeutic Chemical (ATC) classifications. Polypharmacy was defined as use of ≥5 medications. Logistic and negative binomial regression analyses were adjusted for age, sex, education, and BMI.
Results |
Moderate and high PA were associated with significantly lower odds of polypharmacy compared with low PA (AOR=0.37, p = 0.047; AOR=0.08, p = 0.022, respectively). High PA was also associated with a reduced total number of medications (exp(B)=0.44, p = 0.018) and fewer cardiovascular medications (AOR=0.29, p = 0.042). Each additional point in MedDiet adherence was associated with reduced use of alimentary tract and metabolism medications (AOR=0.78, p = 0.016), though no association was found with total medication use or polypharmacy.
Conclusion |
In this cross-sectional study, higher PA was consistently associated with reduced polypharmacy and fewer medications, while greater MedDiet adherence was linked to reduced use of metabolic medications. Lifestyle practices may influence medication use patterns in later life. Larger longitudinal studies are needed to clarify causality and inform strategies to reduce polypharmacy through promotion of healthy lifestyle behaviors.
Le texte complet de cet article est disponible en PDF.Keywords : Older adults, Medication use, Lifestyle factors, Mediterranean diet, Physical activity
Plan
| Dr. Greg Kennedy; PhD; Centre for Mental Health and Brain Sciences, Swinburne University, Melbourne VIC 3122, Australia; Centre for Mental Health and Brain Sciences, Swinburne University of Technology, P.O. Box 218, Hawthorn, Victoria, 3122, Australia. |
|
| Prof. Denny Meyer; DBL; Centre for Mental Health and Brain Sciences, Swinburne University, Melbourne VIC 3122, Australia; Centre for Mental Health and Brain Sciences, Swinburne University of Technology, P.O. Box 218, Hawthorn, Victoria, 3122, Australia. |
|
| Prof. Michael Kingsley; PhD; Department of Exercise Sciences, University of Auckland, New Zealand and Holsworth Research Initiative, La Trobe University, Australia; Department of Exercise Sciences, University of Auckland, New Zealand; Holsworth Research Initiative, La Trobe University, Australia and Holsworth Research Initiative, La Trobe Rural Health School Science, La Trobe University, Flora Hill Campus, Bendigo, Victoria, 3550, Australia. |
|
| Prof. Catherine Itsiopoulos; PhD; School of Health and Biomedicine STEM College, RMIT University, Australia; School of Health and Biomedical Sciences, STEM College, RMIT University, Building 215, Bundoora 3083 Australia. |
|
| Prof. Leonie Senegal; PhD; Health Economics and Social Policy, Allied Health and Human Movement, University of South Australia; SAHMRI building North Terrace Adelaide South Australia 5000. |
|
| Prof. Anne-Marie Minihane; PhD; Nutrition and Preventive Medicine, Norwich Medical School University of East Anglia, Norwich UK; Nutrition and Preventive Medicine, Norwich Medical School, BCRE, Rosalind Franklin Road, University of East Anglia (UEA), NORWICH, NR4 7UQ, UK |
|
| Associate Prof. Karen Murphy; PhD; Alliance for Research in Exercise, Nutrition and Activity (ARENA), Clinical Health Sciences, University of South Australia, Australia; Clinical and Health Sciences, Alliance for Research in Exercise, Nutrition and Activity (ARENA), University of South Australia, GPO Box 2471, Adelaide 5001 Australia. |
|
| Associate Prof. Tuan Anh Nguyen; PhD; Social Gerontology Division, National Ageing Research Institute, Australia and Department of Psychological Sciences, School of Health Sciences, Swinburne University of Technology, Australia and Quality Use of Medicines and Pharmacy Research Centre, UniSA Clinical & Health Sciences, University of South Australia, Australia; Aged Care and Social Gerontology Division, National Ageing Research Institute, 34-54 Poplar Road, Gate 4, Building 8 , Royal Melbourne Hospital, Parkville, Victoria 3052, Australia and Department of Psychological Sciences, School of Health Sciences, Swinburne University of Technology, ATC915 Hawthorn Campus, John St, Hawthorn, Victoria 3122, Australia and Quality Use of Medicines and Pharmacy Research Centre, UniSA Clinical & Health Sciences, University of South Australia, UniSA City East Campus, Corner of North Terrace and Frome Road, Adelaide, South Australia 5001, Australia. |
|
| Jeffery M Reddan; Centre for Mental Health and Brain Sciences, Swinburne University, Melbourne VIC 3122, Australia; Centre for Mental Health and Brain Sciences, Swinburne University of Technology, P.O. Box 218, Hawthorn, Victoria, 3122, Australia. |
|
| Prof. Joris C. Verster; PhD; Centre for Mental Health and Brain Sciences, Swinburne University, Melbourne, VIC 3122, Australia and Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584CG Utrecht, The Netherlands and Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, D-01307 Dresden, Germany; Utrecht University, Utrecht Institute for Pharmaceutical Sciences (UIPS), Division of Pharmacology, Universiteitsweg 99, 3584CG, Utrecht, The Netherlands and Swinburne University of Technology, Centre for Mental Health and Brain Sciences, Melbourne, VIC 3122, Australia and Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Dresden, D-01307, Germany. |
|
| Prof. Andrew Pipingas; PhD; Centre for Mental Health and Brain Sciences, Swinburne University, Melbourne, VIC 3122, Australia; Centre for Mental Health and Brain Sciences, Swinburne University of Technology, P.O. Box 218, Hawthorn, Victoria, 3122, Australia. |
Vol 14
Article 100041- 2025 Retour au numéro
Article précédent
- Predicting dementia risk using neuroimaging and cognitive assessment
- Yu Wang, William Guiler, Ankit Patel, Sam Pepper, Nithmi Walpitage, Isuru Ratnayake, Robyn Honea, Dinesh Pal Mudaranthakam
- Association of psychological stress and subjective cognitive decline
- Manju Ramakrishnan, Nikhila Gandrakota, Yash Kamdar, Ambar Kulshreshtha
Bienvenue sur EM-consulte, la référence des professionnels de santé.