This article illustrates the successful treatment of scissor bite correction using facemask, clear aligner appliances and miniscrew anchorage. An 11- and 3-month-old girl presented with crossbite as the main complaint. The patient was diagnosed with an Angle Class III malocclusion with severe unilateral scissor bite. An Anglebutton™ on the clear aligner appliance and a facemask were used to protract the maxilla during the first set of aligner treatments. Miniscrews were inserted into the posterior region to correct the scissor bite and to intrude posterior teeth, in combination with aligners and occlusal pads on the healthy occlusion side. Because of the attachments on the occlusal surface and the bite-plane effect of aligners, the scissor bite was unlocked and corrected effectively within a short time. The total active treatment period was 17 months. The treatment suggested that the combined use of miniscrew anchorage, clear aligner appliances, and facemask (FM) increased the efficiency of skeletal class III malocclusion with severe unilateral scissor bite correction.