Introduction: Sclerotherapy is a minimally invasive technique that offers an effective alternative to surgical management of chronic venous insufficiency. Despite its growing use worldwide, its application remains underreported in Sub-Saharan Africa. This preliminary study aims to evaluate the clinical outcomes and therapeutic value of sclerotherapy in patients with superficial chronic venous disease at Abidjan Heart Institute.

Methods: A retrospective, descriptive and analytical study was conducted from November 2023 to July 2025. All patients who underwent sclerotherapy for chronic venous insufficiency were included. A total of 64 cases were reviewed.

Results: Among the 64 patients, women accounted for 56.2% of the cohort, although men presented with more advanced and symptomatic disease, including venous claudication, and ulceration. The great saphenous vein was the most frequently treated segment (60.9%). Symptomatic relief was achieved in 85.9% of patients. Duplex ultrasound confirmed successful venous occlusion in all cases. A palpable indurated cord was observed in 100% of patients, consistent with expected post-sclerotherapy changes. Ulcer healing in 3 months was encouraging (31.25%). Sclerotherapy should only be performed under ultrasound guidance to improve accuracy and safety. In addition, no significant complications were observed during the six-month follow-up period. Minor events included hyperpigmentation and transient pain, managed conservatively.

Conclusion: Sclerotherapy proves to be a safe, effective, and well-accepted therapeutic option in the Ivorian context. In the absence of endovenous thermal ablation facilities, it offers a credible alternative to conventional venous surgery, particularly in resource-limited settings.