S46-02 Influence of the mother’s emotional state on infant irritability is moderated by the 5-HTTLPR polymorphism - 17/03/09
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Résumé |
The serotonin transporter gene-linked polymorphic region (5-HTTLPR) may moderate an individual’s response to stress. This study analyzes how the infant 5-HTTLPR may interact with the level of their mother’s emotional state to affect infant irritability.
A prospective study was carried out with 314 newborns and their mothers. Infant irritability and the mother emotional state were evaluated at 8 and 32 weeks after childbirth. These variables were correlated with the 5-HTTLPR genotypes of both the infants and their mothers. The irritability score of infants with the s allele of 5-HTTLPR showed a linear relationship with their mother’s anxiety at both 8 (P= 0.009) and 32 weeks (P= 0.008). In Infants carrying the ll genotype irritability was independent of their mother’s anxiety.
This study provided evidence that the promoter 5-HTTLPR polymorphism could moderate the influence of the mother’s anxiety on infant irritability.
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Vol 24 - N° S1
P. S237 - 2009 Retour au numéro
Article précédent
- S46-01 The impact of paternal depression in infancy: A mechanism for the intergenerational transmission of risk
- V. Sethna, L. Murray, L. Psychogiou, P. Ramchandani
- S46-03 Substance use during pregnancy, postpartum depression and child outcomes: A longitudinal study
- M. Imaz, E. Gelabert, P. Navarro, J. Sanjuan, R. Guillamat, A. Gutierrez, I. Gorneman, F. Canellas, M. Gratacós, X. Costa, M. Torrens, L. García-Esteve, R. Martín-Santos
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