P01-114 A randomized and double- blind clinical trial of venlafaxine hydrochloride sustained release capsules for treating juvenile depression - 17/03/09
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Résumé |
Object |
To evaluate the efficacy and safety of venlafaxine hydrochloride(HCL) sustained release capsules in treating juvenile with depressive disorder.
Methods |
A randomized, double blind dummy clinical trial enrolled 60 adolescent patients with depression, who were randomizedly designed to administer venlafaxine HCL sustained release capsules 150 mg or fluoxetine 20 mg daily for 8 weeks. The efficacies of both treatment groups was evaluated based on the Hamilton Depression Scale and Clinical General impression Scale pre and post-treatment.
Results |
The scores of Hamilton Depression Scale at the end of therapy were significantly reduced compared with the baseline in both gtnups (P< 0.O1). The effective rate of venlafaxine HCL sustained release capsules versus fluoxetine treatmlent was 70.0% and 65.5%, respectively, the P value showed no statistical difference (P>0. OS). The common adverse reactions included dry mouth, insomnia, dizziness, and loss of appetite.
Conclusion |
Venlafaxine HCl sustained release capsules is an effective agent for juvenile with major depression.
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Vol 24 - N° S1
P. S502 - 2009 Retour au numéro
Article précédent
- P01-113 Effectiveness and tolerability of escitalopram in the treatment of depression with or without mental and/or somatic comorbidities
- A. Yfantis, D. Giailoglou, E. Chourdaki, K. Sotiriadou, N. Laggis, S. Markoula, M. Sotiriou
- P01-115 The use ofsertraline in psychiatric practice
- N. Zivlak - Radulovic, M. Miskovic, D. Zoric, T. Maglov, D. Ilic
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