It has been suggested that increased oxidative stress may be both a cause as well as a consequence of hypertension. We studied the effect of oral administration of an antioxidant peptide, taurine (2 g for 15 days) on blood pressure in 14 patients with borderline hypertension in a double-blind, placebo-controlled fashion. Systolic blood pressure after two weeks treatment with taurine decreased by 2.0 +/- 0.5 mm Hg (mean +/- SE ; p less than .05 by paired t test), compared with a 0.7 +/- 0.9 mm Hg decrease (NS) after the same treatment with placebo. Diastolic blood pressure after two weeks treatment with taurine decreased by 2.1 +/- 0.7 mm Hg (p less than .05) compared with 1.1 +/- 2.9 mm Hg (NS) after the same treatment with placebo. Total antioxidant activity of plasma increased after two weeks treatment with taurine from 1.69±0.08 to 1.89±0.05 mmol/L. This trial demonstrated the beneficial effect of taurine as antioxidant on blood pressure in borderline hypertensive men who were not taking antihypertensive medication.Le texte complet de cet article est disponible en PDF.